Fitness and Longevity in Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 主要终点
- Change from baseline Cardiorespiratory Fitness at 16 weeks
研究概览
简要总结
The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity.
详细描述
The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise (AEX) training in older HIV-infected adults. Funding was provided by K23 AG024896 (PI, Oursler) and the UMB Claude D. Pepper Older Americans Independence Center P60 AG12583 (PI, Goldberg).
The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults.
The study met its objectives:
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Scientific AIMS met:
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High-intensity AEX training significantly increases aerobic capacity
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Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance.
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Activity of skeletal muscle oxidative enzymes is reduced, and associated with aerobic capacity.
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Feasibility Objectives met:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable combination antiretroviral therapy (cART)
排除标准
- •AIDS defining conditions in the prior six months
- •Conditions that increase the risk of exercise training per the American College of Sports Medicine (ACSM)
结局指标
主要结局
Change from baseline Cardiorespiratory Fitness at 16 weeks
时间窗: 16-weeks
Cardiorespiratory Fitness measured by VO2peak
次要结局
- Change from baseline body composition at 16 weeks(16-weeks)
- Change from baseline Six-minute walk distance at 16 weeks(16-weeks)
- Change from baseline exercise endurance at 16 weeks(16-weeks)
研究者
KrisAnn Oursler
Physician
University of Maryland, Baltimore