Oral versus Intravenous Hydration to Prevent Contrast Induced Nephropathy - Oral versus Intravenous Hydration to Prevent Contrast Induced Nephropathy

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 2,200 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•Adult patients >18 years undergoing an elective procedure involving intravascular administration of iodinated contrast media and at high risk for the development of Contrast Induced Nephropathy (as defined by guideline criteria).
•High Risk (HR)
•eGFR<45ml/min/1.73m2
•eGFR<60ml/min/1.73m2 and diabetes mellitus
•eGFR 45-60 ml/min/1.73m2 and >= 2 risk factors:
•- Peripheral Arterial Disease
•- Heart Failure
•- Age >75 yrs
•- Anemia (Ht <0.39* and <0.36*)
•- Dehydration
•- Use of diuretics and/or NSAID*s
•- Symptomatic hypotension
•- High volume contrast >150ml
•- Cardiological intervention
•eGFR<45ml/min/1.73m2

•Age <18 years
•Low risk for the development of CIN, therefore no need for hydration (see table).
•Emergency contrastprocedure.
•Overt signs of overhydration; orthopnea or pulmonal rales at the time of the first consult.
•Double or triple diuretic use for pre-existing heart failure.
•Severe renal failure (CKD stage V eGFR<15ml/min/1.73m2)
•Multiple Myeloma.
•Repeated contrast exposure <2 weeks
•Unstable serum creatinine >25% change <6 weeks
•The inability to provide written informed consent.
•Participation in another intervention study

发起方

niversitair Medisch Centrum Sint Radboud