Heat Waves and the Elderly With COPD: Reducing Thermal and Cardiovascular Consequences
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Core body temperature
研究概览
简要总结
The purpose of this study is to investigate thermoregulatory responses in older individuals with COPD.
详细描述
Heat waves are the leading cause of death among natural disasters in the United States.
Elderly individuals are disproportionately more likely to become ill or die during heat waves. While the elderly have a reduced ability to regulate their body temperature,8-10 hospitalizations and deaths in this population during heat waves are primarily due to cardiovascular and/or respiratory complications, not solely hyperthermia. While previous research has primarily focused on the thermal and cardiovascular consequences of healthy aging, very little research has focused on the physiological responses to heat exposure in older individuals with chronic disease, such as chronic obstructive pulmonary disease (COPD). Notably, epidemiological data suggests that pulmonary complications are a leading cause of heat wave-related hospitalizations in older adults with a diagnosis of COPD, yet nothing is known regarding the physiological mechanisms by which those with COPD are most susceptible to heat waves. To fill this important gap, the investigators will identify the physiological responses that occur in this population, relative to healthy age-matched individuals, during two unique heat wave simulations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —(Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •65 years old or older
- •Diagnosis of COPD
排除标准
- •Known heart disease
- •Other chronic medical conditions requiring regular medical therapy including cancer, diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia etc
- •Abnormality detected on routine screening suggestive of provokable ischemia or previously undetected cardiac disease or resting left bundle branch block on screening electrocardiogram
- •Current smokers
- •Participant with a body mass index ≥31 kg/m2
研究组 & 干预措施
Experimental: Very hot and dry
Subjects will be exposed to 3 hours in a climate chamber set to approximately 47 deg C and 15% relative humidity, which reflects a very hot and dry heat wave condition similar to the 2018 Los Angeles heat wave. Two visits will be required to complete this arm, with one visit including water spray for cooling.
干预措施: Control (Other)
Experimental: Hot and humid
Subjects will be exposed to 3 hours in a climate chamber set to approximately 41 deg C and 40% relative humidity, which reflects hot and humid heat wave similar to the 1995 Chicago heat wave. Two visits will be required to complete this arm, with one visit including water spray for cooling.
干预措施: Control (Other)
Experimental: Hot and humid
Subjects will be exposed to 3 hours in a climate chamber set to approximately 41 deg C and 40% relative humidity, which reflects hot and humid heat wave similar to the 1995 Chicago heat wave. Two visits will be required to complete this arm, with one visit including water spray for cooling.
干预措施: Water Spray (Other)
Experimental: Very hot and dry
Subjects will be exposed to 3 hours in a climate chamber set to approximately 47 deg C and 15% relative humidity, which reflects a very hot and dry heat wave condition similar to the 2018 Los Angeles heat wave. Two visits will be required to complete this arm, with one visit including water spray for cooling.
干预措施: Water Spray (Other)
结局指标
主要结局
Core body temperature
时间窗: Prior to and throughout each simulated heat wave exposure, an average of 480 minutes
Core body temperature will be measure from gastrointestinal temperature via an ingestible telemetric pill
Forced vital capacity (FVC)
时间窗: Prior to, during, and after each simulated heat wave exposure, approximately 10 min each
FVC will be assessed via spirometry
Forced expiratory volume (FEV1)
时间窗: Prior to, during, and after each simulated heat wave exposure, approximately 10 min each
FEV1 will be assessed via spirometry
FEV1/FVC ratio
时间窗: Prior to, during, and after each simulated heat wave exposure, approximately 10 min each
The ratio of forced expiratory volume and forced vital capacity will be assessed via spirometry
次要结局
未报告次要终点
研究者
Craig Crandall
Professor of Internal Medicine
University of Texas Southwestern Medical Center
