NL-OMON42199已完成不适用
The effects of statins on skeletal muscle mitochondria:a pilot study? - Statins and mitochondria
Integrative fysiologie0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •o Age: 18-70 years old
- •o Current statin user: (group 1-2) for at least three months
- •o Mentally able/ allowed to give informed consent
排除标准
- •o familial hypercholesterolemia
- •o history of a cardiovascular event within 1 year of study participatie
- •o impaired liver function ( ALAT, ASAT, gamma-GT > 3x ULN)
- •o known hereditary muscle defect; creatine kinase > 5x ULN
- •known mitochondrial disorder
- •o Medication known to potentially interfere with muscle metabolism (fibrates,
- •Beta blockers, laxatives, diuretics, bronchodilatators)
- •o Impaired kidney function: creatinin <50 or >100 umol/l
- •o Diabetes mellitus
- •o Engagement in exercise for more than two hours per week
- •o contraindications for the exercise test (as explained in the protocol and the SOP) or muscle biopsy (see SOP)
研究者
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