Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Description of intracellular pathways to clarify the interplay between calorie restriction, SIRT1, STATb5, and the GH/IGF-I axis
研究概览
简要总结
This study will investigate whether growth hormone is modulated by the enzyme SIRT1 and by that is stimulating lipolysis on expense of IGF-I production. This is done in 10 healthy men on calorie restriction on 4 study days with fat and skeletal muscle biopsies.
详细描述
It has been shown that calorie restriction enhances the length of life in yeast, worms, fish and rodent. Whether this elongation of life due to calorie restriction can be applied to humans is not known. However, it is a fact that calorie restriction will decrease the risk of developing metabolic disturbances such as diabetes, hypertension and atherosclerosis.
On the molecular level the specific relations are not fully understood. This study will investigate the possible connection between SITR1 and the relation to the GH/IGF-I axis and STAT5b in healthy men. The participant will fast 42 and 12 hours respectively, and have GH or placebo infusions. The design is a classical 2x2 design and will be randomized.
Knowledge of the interactions between calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis will apply important information about the relations between aging, energy metabolism and metabolic disturbances.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy lean men
排除标准
- •metabolic disturbances
- •alcohol drug abuse
- •malign disease: current or previous
研究组 & 干预措施
42 hour fast/GH infusion
干预措施: GH hormone infusion (Drug)
42 hour fast/GH infusion
干预措施: 42 hour fast (Behavioral)
42 hour fast/Placebo infusion
干预措施: 42 hour fast (Behavioral)
12 hour fast/GH infusion
干预措施: GH hormone infusion (Drug)
12 hour fast/GH infusion
干预措施: 12 hour fast (Behavioral)
12 hour fast/Placebo infusion
干预措施: 12 hour fast (Behavioral)
结局指标
主要结局
Description of intracellular pathways to clarify the interplay between calorie restriction, SIRT1, STATb5, and the GH/IGF-I axis
时间窗: 6 hour study days
All study days consists of 3 hour basic periods and 3 hours hyperinsulinemic, euglycemic clamp.
次要结局
未报告次要终点
研究者
Birgitte Nellemann
MD PhD student
University of Aarhus