A Randomised Comparative Clinical Study to evaluate the efficacy of Narayana Ghrita and Jeerakadhya Ghrita in the management of Urdhwaga Amlapitta with special reference to Dyspepsia

Amlapitta is condition where Pitta is accumulated previously from the self aggravating causes, gets Vidagdha due to Virudha, Dustha, Amla, Vidahi, Pittakar Ahara and Drava like Phanita, Kulattha, Ikshu Vikara, Bhristha Dhanya, Pulaka etc. In further days due to repeated Nidanas it get Shuktatva residing in Aamashaya. Amlapitta has symptoms like Avipaka, Klama, Utklesh, Tiktaamlodgara, Gouravata, Hritkantha Daha, Aruchi etc1.

Urdhwaga Amlapitta can be correlated with Dyspepsia in modern science. Its symptoms are like nausea, indigestion , heart burn, sour and bitter belchings, post-prandial fulness etc2,3,4.

Prevalence rate of Dyspepsia in India is 30.4%. Most common symptoms included Abdominal fullness (24%), Abdominal pain (13.6%), Heart burn(10.7%) & Belching(10.6%)5

Dyspepsia affects the personal, mental, professional and economical status of individual life. Treatment modality includes administration of Proton pump inhibitors, H2-blockers and Antacids. Prolonged use of these drugs may cause loss of appetite, nausea, constipation etc6. So these drugs have restrictions of prolonged usage. Thus Ayurveda has scope for this treatment.

In Ayurvedic classics, various therapies like Vamana, Virechana, Snehapana, Rakta Mokshana, Shamana Chikitsa and Rasayana etc are mentioned to manage Amlapitta. Ghrita is having unique quality of Sanskarasya Anuvartanaat, ability to imbibe the qualities of herbs by which it is being processed without loosing it’s basic qualities. In Amlapitta, Ghrita is mentioned as *Pathya.*7 Thus Ghrita is utilized as supreme media for drug administration. Ghrita is Vata-Pittahara, Na Shleshma Vardhana, Daha Shamaka and Agnideepana. hence it is used in the management of Amlapitta8

Amlapitta is Pittapradhan and Saamavyadhi. Kledaka Kapha and Pachaka Pitta are Drava in dominancy. The Dravatah Vriddhi of Pitta reduces the Tikshanata of Pachaka Pitta as well as vitiates Kledaka Kapha leading to Agnimandya and unable to digest even little quantity of food. Narayan Ghrita contains ingredients like Pippali, Shunthi having properties like Katu Rasa, Tikshna Guna, Ushna Virya & Madhura Vipaka. Katuki is having Tikta Rasa, Shita Virya, and Katu Vipaka so used in Vikruta Pitta and Kaphajanya Vikaras. Itdoes Deepana, Pachana, Rochana and Dosha Samshodhan. Due toMadhura Guna of Pippali it acts as Pittashamaka and due to Ushnata, Madhura Vipaka Vatanulomana takes place*.* Guduchi, Amalaki, Draksha does the Shamana of Udrikta Pitta. Ghrita is having Madhura Rasa, Madhura Vipaka, Sheeta Veerya, Pitta-Anilahara, it is having Agnideepaka Tridoshahara property. By these properties it does the Samprapti Vighatana on Amlapitta. Jeerakadhya Ghrita contains Jeeraka which is Agnideepaka& Dhanyaka which is Pittashamak. By considering above qualities drugs are selected for the study of management of Urdwaga Amlapitta.