Efficacy of Cannabidiol (CBD) for Treating Recurrent Aphthous Ulcers

Thailand Science Research and Innovation Fund Chulalongkorn University0 个研究点目标入组 69 人开始时间: 2022年8月2日最近更新: 2024年8月19日

适应症

试验速览

阶段: 2 期
状态: 已完成
发起方
入组人数: 69

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

The present study demonstrated that CBD reduces ulcer size and accelerates ulcer healing without any local or systemic side effects. CBD exerts an anti-inflammatory effect by reducing the erythematous border size in the early stage and decreases pain intensity in the late stage of RAU. Therefore, CBD may be suitable for RAU patients who desire to avoid the use of steroid medications.

研究设计

研究类型: Interventional

入排标准

年龄范围: 18 Years 至 65 Years（—）
性别: All

入选标准

•1. Willing to participate and provide informed consent, 2. Had a history of RAU (at least 2 times/year) on nonkeratinized oral mucosa, 3. Presenting with 1-3 aphthous ulcers (of less than or equal to 48 hours duration) that were 2-10 mm in diameter and easily accessible for evaluation

排除标准

•1. History of allergies to CBD, 2. Pregnancy/lactation, 3. Concurrent oral bacterial/fungal/viral infections, 4. Ulcers as a manifestation of a systemic disease such as Crohn's disease, Behcet's syndrome, or anemia, 5. Ulcers from trauma, 6. Diabetes mellitus patients, 7. Treatment with systemic steroids, oral retinoids, or other immunomodulatory agents within 1 week, 8. Treatment with nonsteroidal anti-inflammatory drugs, acetaminophen, or oral topical medications within 48 hours or during project participation, 9. History of dental surgery within 2 weeks of entering the study, 10. Orthodontic braces or retainers that might come in contact with the ulcer

研究者

发起方

Thailand Science Research and Innovation Fund Chulalongkorn University

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