NCT05252741Unknown不适用
Evaluation Of Levels Of Pigment Epithelium-Derived Factor (PEDF) In Patients With Psoriasis.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- changes in serum and tissue levels of (PEDF) in patients with psoriasis
研究概览
简要总结
Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines. Pigment epithelium-derived factor (PEDF) is one of the most abundant adipokines and have anti-angiogenesis effect. There is a study showed that PEDF level is up-regulated in the sera of psoriasis patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with psoriasis and group of age and sex-matched healthy volunteers will be included as a control group.
排除标准
- •Pregnancy.
- •Patients with other inflammatory skin disorders.
- •Patients on antioxidants or anti-inflammatory drugs.
- •Patients on topical or systemic treatment for psoriasis in the last 4 weeks prior to enrollment in the study.
- •Patients on systemic retinoids (Acitretin).
- •Obesity: body mass index (BMI ) >
- •Malignancies e.g squamous cell carcinoma.
- •Viral warts.
- •Diabetes.
- •Hypertension.
研究组 & 干预措施
Group 1: patients with psoriasis
Active Comparator
干预措施: serum samples and punch skin biopsies (Other)
Group 2: age-, sex-, BMI-, and weight-matched control subjects.
Placebo Comparator
干预措施: serum samples and punch skin biopsies (Other)
结局指标
主要结局
changes in serum and tissue levels of (PEDF) in patients with psoriasis
时间窗: 12 months
evaluate serum and tissue level of (PEDF) in patients with psoriasis.
次要结局
未报告次要终点
研究者
Omnia Ahmed Abdelhafez
Resident of Dermatology, Venereology and Andrology Sohag General Hospital
Sohag University
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Effect of Atopic Diathesis as Assessed by Serum Th1/Th2 Cytokine Profile on Clinical Manifestation of PsoriasisPsoriasisNCT00372580National Taiwan University Hospital110
已完成
3 期
Study of Subcutaneous (Injected Under the Skin) Risankizumab to Assess Change in Disease Symptoms in Adult Participants With Moderate to Severe Plaque Psoriasis With Palmoplantar InvolvementPsoriasisNCT04713592AbbVie174
Unknown
不适用
Clinical Study of PET/CT and Association With Metabolic Syndrome/Depressive Symptoms in PsoriasisPsoriasisDepressionMetabolic SyndromeNCT01661127Pusan National University Hospital10
已完成
3 期
A Study of Subcutaneous Risankizumab Injection for Pediatric Participants With Moderate to Severe Plaque Psoriasis to Assess Change in Disease SymptomsPsoriasisNCT04435600AbbVie139
已完成
不适用
Cytokines and Vascular Inflammation in PsoriasisPsoriasisVascular InflammationCoronary AtherosclerosisNCT02305953Innovaderm Research Inc.96