Comparison Between Two Techniques of Volemic Expansion in Hip Replacement Arthroplasty: Hydroxyethyl Starch Versus Ringer's Lactate
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- HES expansion plasmatic efficacy
研究概览
简要总结
Currently the most use solution to volemic reposition in hip replacement arthroplasty is the crystalloid solution. This trial intends to compare two different volemic replacements: HES and Ringer's lactate. This research has been analyzing hemodynamic parameters and the coagulation status before and after the pre-expansion with the solutions above mentioned.
详细描述
This trial is randomized an blind to the physician who is analyzing the results.It has been select adults; both sex; ASA I and II. These patients must be submitted to hip arthroplasty replacement. The anesthesia technique is single shot spinal anesthesia. Primary endpoint: assessment alternative; technique replacement volemic with HES 130/04. Secondary endpoint: haemostatic abnormalities; blood loss; transfusion blood.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients involved: adults, ASA I and II;
- •Surgery: hip replacement arthroplasty.
排除标准
- •Allergy starch;
- •Dysfunction renal;
- •Heart insufficiency;
- •Morbid obesity.
研究组 & 干预措施
HES 130/04
Pre-expansion with HES
干预措施: Hydroxyethyl Starch (Drug)
Ringer's lactate
Pre-expansion with Ringer's lactate
干预措施: Hydroxyethyl Starch (Drug)
Ringer's lactate
Pre-expansion with Ringer's lactate
干预措施: Ringer's lactate (Drug)
结局指标
主要结局
HES expansion plasmatic efficacy
时间窗: 24 hours
次要结局
- Blood transfusion(24 hours)
- Haemostatic alterations(24 hours)