The Effect of Tyrosine Kinase Receptor Axl on Dialysis Prognosis in Chronic Hemodialysis Patients: a Cohort Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- death
研究概览
简要总结
The purpose of this study is to evaluate whether tyrosine kinase receptor Axl affects the dialysis prognosis in chronic hemodialysis patients
详细描述
It is reported that hemodialysis (HD) patients often develop chronic systemic inflammatoion, and increased inflammatory activity is associated with vascular access failure, cardiovascular disease and death in HD patients. The interaction of Axl and its ligand Gas6 plays an important role in modulating immune response, inhabiting toll-like receptor (TLR) signaling and suppressing inflammatory cytokines production. Thus, we want to investigate the relationship between tyrosine kinase receptor Axl and the dialysis prognosis in HD patients in three-years follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hemodialysis for more than 6 months
排除标准
- •patients who received warfarin therapy;
- •patients with chronic infectious disease or acute infection;
- •patients with hemodialysis inadequacy;
- •the age of patients is older than 65 years or younger than 18 years.
- •patients who can not sign an informed consent or disagree to follow up
结局指标
主要结局
death
时间窗: 3 years
death
dialysis complication
时间窗: 3 years
vascular access failure, stroke, acute coronary syndrome, heart failure
次要结局
未报告次要终点
研究者
Ai Peng
Director of the department of Nephrology,Shanghai 10th people's hospital
Shanghai 10th People's Hospital