Effects of probiotic and prebiotic supplements on serum inflamatory factors, tryptophan, cortisol, leptin and appetite in patients with major depressive disorder

Tehran University of Medical Sciences0 个研究点目标入组 90 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•range for ages 18 to 50 years; mild to moderate melancholic type of major depression; intake of the following anti-depressant drugs: sertraline, fluoxetine and citalopram.
•Exclusion criteria: history of renal, hepatic, cardiovascular, respiratory diseases or food allergy; pregnancy and lactation; regular intake of probiotic less than 2 months before the beginning of the study; intake of the antioxidant or omega 3 supplements 6 weeks before the beginning of the study; alcohol intake; smoking cigarette (more than 5 Sticks during last 6 month) or tobacco (pipe and hookah at least one time during last month); any addiction to opiates; history of heart attack or stroke; following of specific diet; participation in another study during last two months; intake of drugs other than antidepressant drugs; allergy to the components of study supplements; any significant change in the diet and life style; any change in the drug regiment; inflammatory disease which last more than one week during the study; intake of antibiotics during the study.

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