A Prediction Model of Anastomotic Stricture After Rectal Cancer: a Retrospective Cohort Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,542
- 试验地点
- 1
- 主要终点
- patients without anastomotic stricture
研究概览
简要总结
Background: Anastomotic stricture significantly impacts patients' quality of life and long-term prognosis. However, current clinical practice lacks accurate tools for predicting anastomotic stricture. This study aimed to develop a nomogram to predict anastomotic stricture in patients with rectal cancer who have undergone anterior resection.
Methods: 1542 eligible patients will be recruited for the study. Least absolute shrinkage selection operator (Lasso) analysis will be used to preliminarily select predictors. A prediction model will be constructed using multivariate logistic regression and presented as a nomogram. The performance of the nomogram will be evaluated using receiver operating characteristic (ROC) curves, calibration diagrams, and decision curve analysis (DCA). Internal validation will be conducted by assessing the model's performance on a validation cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pathological confirmation of rectal cancer;
- •eligibility for surgical intervention;
- •undergoing first rectal cancer surgery;
- •acquisition of written informed consent from patients and their families;
- •no history of hypertrophic scar or allergic predispositions.
排除标准
- •absence of postoperative follow-up or anastomosis details;
- •patients subjected to Hartmann or Miles procedures;
- •emergency surgery candidates due to conditions like perforation or obstruction;
- •diagnosis of multiple primary malignancies;
- •intraoperative discovery of widespread implant metastases within the abdominal cavity;
- •severe comorbidities;
- •anastomotic recurrence of rectal cancer;
- •patients who had undergone stapled hemorrhoidopexy
结局指标
主要结局
patients without anastomotic stricture
时间窗: up to six months
Within six months after rectal cancer surgery, the patient was not diagnosed with benign stricture of the rectal anastomosis
patients with anastomotic stricture
时间窗: up to six months
Within six months after rectal cancer surgery, the patient was diagnosed with benign stricture of the rectal anastomosis
次要结局
未报告次要终点
研究者
Daorong Wang
Clinical Professor
Northern Jiangsu People's Hospital