Steady State Kinetics of l-Methamphetamine and Validation of Sensitivity of Dose Estimation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Serum samples
研究概览
简要总结
The intent of this study is to see if the rate that the body breaks down l-methamphetamine (l-MA) could be used as an accurate estimate for the rate that the body breaks down d-methamphetamine (d-MA). l-MA is sold over the counter as a nasal decongestant where as d-MA is the commonly abused form of methamphetamine.
详细描述
Subjects will screen at St. Luke's Hospital in San Francisco to determine their eligibility.
Once enrolled the study will take two weeks. During the first week subjects attend daily, hour-long outpatient visits at San Francisco General Hospital. At these visits subjects will receive an oral dose of l-methamphetamine, have their vitals read, answer questionnaires and receive a blood draw.
During the second week of the study subjects are admitted to San Francisco General Hospital for a week long inpatient stay. During this stay the subject continues to receive l-methamphetamine but also receives three doses of d-methamphetamine on three separate days. In addition the subject receives blood draws, has their urine collected, and answers questionnaires.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy Males and Females Between the Ages of 18 and 50
- •Must have some experience with methamphetamine
排除标准
- 未提供
研究组 & 干预措施
l-methamphetamine
干预措施: l-methamphetamine (Drug)
l-methamphetamine
干预措施: d-methamphetamine (Drug)
结局指标
主要结局
Serum samples
时间窗: Predose and Multiple Timepoints Post Doses
Urine Samples
时间窗: 24 Hour Inpatient Collection
次要结局
- Questionnaries(Predose and Multiple Timepoints Post Doses)
研究者
John Mendelson, MD
Senior Scientist
California Pacific Medical Center Research Institute