ACTRN12618001229268招募中3 期
aparoscopic Appendicectomy versus Antibiotics for Resolution of Radiologically Confirmed Acute Uncomplicated Appendicitis: A Multi-Centre Randomised Pilot Tria
Townsville Hospital0 个研究点目标入组 40 人开始时间: 2018年7月23日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 50 Years（—）
- 性别
- All
入选标准
- •1. Clinical diagnosis of appendicitis as per treating physician.
- •2. Radiological evidence of appendicitis on Ultrasound or Computed Tomography scan.
排除标准
- •Medical Exclusion Criteria:
- •Age < 18 or > 50
- •Severe sepsis / septic shock
- •Peritonitis
- •Abdominal surgery within last month
- •Received antibiotics within last week
- •Allergy to study medications (i.e. antibiotic regimen, paracetamol)
- •Comorbidity exclusion criteria
- •Complex diabetes: requiring any medication (e.g. metformin, insulin), ketoacidosis or coma
- •Immunodeficiency
- •Ischaemic heart disease, Congestive heart failure, Congenital heart disease
- •Cardiac surgery or coronary stents
- •Takin aspirin, antiplatelet, anticoagulant medications
- •History of bleeding disorders
- •History of chronic liver disease, cirrhosis, liver failure
- •Chronic renal insufficiency (eGFR < 40), haemodialysis, peritoneal dialysis, plasmapheresis
- •Concurrent severe illness requiring hospitalization
- •Other infection requiring antibiotic treatment
- •Intravenous drug use (ever)
- •Cognitive impairment, intellectual disability, severe mental illness
- •Previous colonic or small bowel surgery
- •Any active malignancy apart from non-metastatic skin cancer
- •Logistical Exclusion Criteria
- •Inability/unwilling to return for follow up
- •Inability to provided written informed consent
- •Non-English speaker
- •Aboriginal and Torres Strait Islander heritage
- •Radiological Exclusion Criteria
- •CT / USS evidence of complicated appendicitis (phlegmon, abscess, perforation)
- •Presence of faecolith
- •Any radiological suspicion for alternative diagnosis or malignancy
研究者
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