A Multicenter Randomized in Primary Livertransplantation Comparing Longterm Renal Function in Recipients Treated With Tacrolimus Alone and Recipients Treated With a Combination Tacrolimus and Sirolimus
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 196
- 试验地点
- 3
- 主要终点
- Renal function
研究概览
简要总结
In this study we compare long term renal function in liver transplantation recipients treated with standard dose extended-release tacrolimus alone and recipients treated with a combination of low dose extended-release tacrolimus and low dose sirolimus. The hypothesis is that the patients treated with the combination have better long term renal function than the patients treated with standard dose tacrolimus alone.
详细描述
To evaluate the effectiveness and safety of concentration controlled combination of once daily dosed low-dose sirolimus (trough levels: 3-5 ng/ml) and extended-release tacrolimus (trough levels:3-5 ng/ml), in order to provide superior renal function while maintaining comparable rates of patient and graft survival, compared to concentration controlled once - daily extended release tacrolimus (trough levels: 5-10 ng/ml) at 12, 24 and 36 months post-transplant. Moreover, to compare the incidence of de novo malignancy, the quality of life, fatigue and side effects between both treatment arms.
2.1 Primary objectives: To evaluate the effectiveness and safety of concentration controlled combination of low-dose sirolimus (trough levels: 3-5 ng/ml) and extended-release tacrolimus (trough levels: 3-5 ng/ml), in order to provide superior renal function while maintaining comparable rates of patient and graft survival, compared to concentration controlled once - daily extended release tacrolimus (trough levels:-10 ng/ml) control at 12, 24 and 36 months post-transplant.
2.2. Secondary objectives:
- To compare the incidence of de novo and recurrence of cancer between study arm and control arm at 36 months.
- To compare the incidence and severity of biopsy proven acute rejection between study arm and control arm at 12, 24 and 36 months.
- To evaluate renal function at 12, 24 and 36 months (calculated GFR).
- To evaluate the development of new onset diabetes mellitus at 12, 24 and 36 months post transplant
- To evaluate the prevalence of CNI side effects at 12, 24 and 36 months
- To evaluate quality of life (Eq5D) and fatigue severity score at 12, 24 and 36 months
- To evaluate the percentage of patients on combination tacrolimus and sirolimus and converted back to tacrolimus mono-therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary liver transplantation or retransplantation within 14 days after first transplantation
- •Use of Advagraf at least 2 weeks prior to randomization
- •Patent hepatic artery
- •Closed abdominal wound
- •Stable graft function
- •Positive informed consent at time of randomization
- •Age 18-70 years
排除标准
- •Treatment with investigational drugs within 3 months before start of therapy
- •Multi organ transplantation
- •cGFR < 30 ml/min
- •Proteinuria > 800 mg/24 h
- •Hyperlipidemia refractory to optimal medical management (Cholesterol > 9 mmol/l and/or triglycerides > 8.5 mmol/l). Patients with controlled hyperlipidemia are acceptable at the time of randomization.
- •Known hypersensitivity to sirolimus or its derivatives
- •Thrombocytes < 50 x 109 /L
- •Leukocytes < 2.5 x 109 /L
- •Haemoglobin < 6 mmol/L
- •Biopsy proven rejection 2 weeks prior to randomization
- •HIV positivity
- •Signs of recurrent or de novo cancer
- •Patients with non-HCC malignancies within the past 5 years (excluding successfully treated squamous cell carcinoma and basal cell carcinoma of the skin)
- •Evidence of significant local or systemic infection
- •Pregnancy or breast feeding
- •Women of child-bearing potential not willing to take oral contraception
- •Any other condition which in the opinion of the investigator would make the patient unsuitable for enrollment, or could interfere with the patient participating in and completing the study
研究组 & 干预措施
Tacrolimus
Patient received standard-dose of Tracrolimus Advagraf (5-10 ng/ml) and 7.5 mg prednison; lower or discontinue steroids after day 180 at the discretion of the treating physician
干预措施: Tacrolimus (Drug)
combination Tacrolimus and Sirolimus
Patients receive combination of low-dose extended release Tacrolimus and low-dose Sirolimus
干预措施: Tacrolimus and Sirolimus (Drug)
结局指标
主要结局
Renal function
时间窗: 3 years
Percentage of patients with cGFR \< 60ml/min
次要结局
- Diabetes Mellitus(3 years)
- Malignancies(3 years)