A randomised controlled trial to evaluate invitation to community-based low dose computed tomography (LDCT) screening for lung cancer versus usual care in a targeted population at risk

niversity of Leeds0 个研究点目标入组 6,892 人开始时间: 2018年4月3日最近更新: 2024年7月29日

适应症

试验速览

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32912947/ (added 15/09/2020) 2023 Interim results article in https://pubmed.ncbi.nlm.nih.gov/37612098/ (added 25/08/2023) 2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38986555/ Protocol for a nested randomised controlled trial (added 11/07/2024)

•The inclusion criteria for entry into the randomisation cohort are:
•1. Registered with a participating General Practice within the Leeds CCG area
•2. Registered as current or ex-smoker in primary care databases
•3. Age between 55 and 80 years (inclusive) at the time of randomisation
•The inclusion criteria for being invited to attend a mobile lung health check following contacting the telephone triage service are any of:
•1. 30 pack year history of smoking and current smoker, and quit within the last 15 years, (USPSTF criteria)
•2. Lung cancer risk of =1.51% over 6 years as calculated by the PLCOM2012 score
•3. Lung cancer risk of =5% over 5 years as calculated by the LLPv2. score

•1. Unable to provide written informed consent
•2. Diagnosed with lung cancer within past 5 years
•3. Diagnosed with incurable cancer
•4. CT thorax within past 12 months
•5. Registered on any of the following primary care databases:
•5.1. Palliative care register
•5.2. Dementia register
•5.3. Frailty index > (to be decided)
•6. Recorded type 2 objection to participation in the General Practice Extraction Service

发起方

niversity of Leeds