Effectiveness of Diclofenac versus Paracetamol in primary care patients with knee osteoarthritis. - DIPA-trial

Erasmus Medical Center; Department of general practice0 个研究点目标入组 154 人开始时间: 2008年11月24日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•- Patients consulting for a new episode with non-traumatic knee pain in the general practice.
•- Complying to the clinical American College of Rheumatology (ACR) criteria for osteoarthrosis of the knee.
•- Have an indication for pain medication.
•- A score of 3 or more on the pain severity scale (0-10 scale).
•- Patients’ aged 45 years or older.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•- Contra-indication for NSAID or Paracetamol use (these are: Gastrointestinal bleedings in history or active, blood dyscrasia, bone marrow depression, serious heart failure, serious liver or kidney disease (glomerular filtration < 30 ml/min), known alcoholism, Colitis Ulcerosa, Crown disease, sulphite hypersensitivity, appearance of asthma, urticaria, angioedema, nasal polyps or rhinitis after use of acetylsalicylic acid or other prostaglandin synthetase inhibitors, or use of anti-depressives (SSRIs).
•- An arthroplasty or osteotomy of the knee in contralateral or unilateral side.
•- Already taking NSAID or paracetamol medication of similar or higher doses as in the study.
•- Surgery or major trauma of the affected joint within the previous 6 months.
•- Pregnancy.
•- Use of corticosteroid of hyaluronic acid.

发起方

Erasmus Medical Center; Department of general practice