Helium 4 Optically Pumped Magnetometers : a New Generation of Sensors for High Speed Functional Brain Imaging
试验速览
- 阶段
- 不适用
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Signal to Noise Ratio of the recorded brain activities
研究概览
简要总结
Our goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography sensors (OPM He4) to record brain magnetic activities. The investigator will record 1) normal subjects stimulated with visual, auditory, somesthesic and motor stimuli and 2) epileptic patient. The investigator will compare the signal to noise ratio of the normal or pathological activities between classical MEG sensors and our OPM He4 prototype.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Volunteers:
- •Right handed
- •Medical insurance
- •Strongly motivated to participate to the study
- •Signed informed consent for the study
- •No previous neurology or psychiatric pathologies
- •No major cognitive deficit and able to understand the instructions
- •Right handed
- •Medical insurance
- •Strongly motivated to participate to the study
- •Signed informed consent for the study
- •No previous neurology or psychiatric pathologies (except epilepsy)
- •Epilepsy evolving during at least two years
- •No major cognitive deficit and able to understand the instructions
排除标准
- •Volunteers:
- •Age < 18 years or > 60
- •previous neurology or psychiatric pathologies
- •Child bearing women
- •Subject having one of the following mettalic parts :
- •(pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve)
- •Claustrophobia Woman with a positive pregnancy test during the inclusion.
- •Age < 18 years or > 60
- •previous neurology or psychiatric pathologies except epilepsy
- •Child bearing women
- •Subject having one of the following mettalic parts :
- •(pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve)
- •Claustrophobia Woman with a positive pregnancy test during the inclusion.
结局指标
主要结局
Signal to Noise Ratio of the recorded brain activities
时间窗: 1 month
Volunteers: The signal to noise ratio of normal brain activity following a stimulus will be computed with respect to the pre-stimulus baseline -100ms to -10 ms. Epileptic patient: The signal to noise ratio of abnormal epileptic brain activity will be computed with respect to a 100 ms baseline not containing any abnormal activity.
次要结局
- Signal to Noise Ratio of pre-frontal auditory activity(one month)
- Signal to Noise Ratio of high frequency epileptic activity(one month.)
- Comfort of the subject during the MPO He4 recordings for epileptic patient through a short verbal questionary(5 minutes after the end the recording session)
- Comfort of the subject during the MPO He4 recordings for volunteers through a short verbal questionary(5 minutes after the end of each recording session)