Evaluation of Impaired Sedation in Patients With Moderate to Severe COVID-19 ARDS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- Agitation and sedation level
研究概览
简要总结
This study focuses on the evaluation of various factors repeatedly discussed in relation to the impaired sedation of intubated ventilated COVID-19 patients. The sedation response of >100 moderately to severely affected COVID-19 ARDS was evaluated. The sedation level was measured at the bedside using the Richmond Agitation and Sedation Scale and ventilator synchrony. The evaluation was performed according to the static evaluation plan with respect to age, storage therapy and organ failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •moderate to severe COVID-19 ARDS
排除标准
- 未提供
结局指标
主要结局
Agitation and sedation level
时间窗: Change in average dosage within 8 hours.
Change of sedation level using the Richmond Agitation and Sedation Scale (RASS, range: -5\[Unarousable\] to +4 \[Combative\], normal condition=0 \[Alert and calm\])
Change in sedative dosage applied
时间窗: Change in average dosage within 8 hours.
Applied dosage of esketamine (measured in mg/kg/h)
Application of sedative
时间窗: 30 minutes after study enrolment
Applied dosage of esketamine (measured in mg/kg/h)
Application of opioid analgesic
时间窗: 30 minutes after study enrolment
Applied dosage of remifentanil (measured in µg/kg/min)
Patient Characteristics
时间窗: The data is recorded at the time of enrolment
Weight (in kilograms)
Position therapy
时间窗: Data collection is performed at the date of death from any cause or discharge up to 10 weeks.
Number of positioning therapys during treatment
Change of application of opioid analgesic
时间窗: Change in average dosage within 8 hours.
Applied dosage of remifentanil (measured in µg/kg/min)
次要结局
- Need for renal replacement therapy(Data collection is performed at the date of death from any cause or discharge up to 10 weeks.)
- Need for extracorporeal membrane oxygenation (vvECMO)(Data collection is performed at the date of death from any cause or discharge up to 10 weeks.)
研究者
Elisabeth H. Adam
Senior Physician
Goethe University