NCT00862290已完成不适用
Diagnostic and Predictive Value of Circulating microRNAs During Sepsis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Relative amount of circulating microRNAs
研究概览
简要总结
MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients who develop sepsis and undergo abdominal surgery
- •patients who develop SIRS after cardiac surgery with cardiopulmonary bypass
排除标准
- •patients with a primary diagnosis of acute pancreatitis
- •patients with cirrhosis or renal dysfunction
- •patients with dyscrasia
- •patients with autoimmunity diseases
- •patients with severe cardiac and pulmonary diseases
- •patients with hematological diseases
- •patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass
结局指标
主要结局
Relative amount of circulating microRNAs
时间窗: On the second day of diagnosis of sepsis in ICU
次要结局
- Apache II score and death(On the second day of diagnosis of sepsis)
- Serum levels of CRP and IL-6(On the second day of diagnosing sepsis)
研究者
研究点 (1)
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