Acute Effect of Individual Variants of Agonist-antagonist and Traditional Agonistic Resistance Training on Cardiovascular Parameters in Patients With Normotension and 1 Stage of Hypertension.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 47
- 试验地点
- 4
- 主要终点
- Arterial stiffness - Pulse wave velocity
研究概览
简要总结
Prevention and non pharmacological treatment of prehypertension and hypertension stage 1
The effect of individual variants of agonist-antagonist and traditional agonistic resistance training on cardiovascular parameters in individuals with normotension and hypertension.
What does the study involve?
- Cardiovascular parameters
- Body composition
- Blood tests for heart disease
- Training intervention
A. Resistance training protocol: 75% 1RM, 10 reps, 3 sets, 2 min rest between sets and exercises, 16 exercises
- Agonistic RT - upper body
- Agonistic RT - lower body
- Agonist-Antagonist - upper body
- Agonist-Antagonist - lower body B. Aerobic training: 60% SF max, 4 x 10 min, 2 min rest between sets
- Intraabdominal wall tension activity
- The Borg rating of perceived exertion
- Handgrip testing
- Repetition testing (RM)
详细描述
The effect of individual variants of agonist-antagonist and traditional agonistic resistance training on cardiovascular parameters in individuals with normotension and hypertension.
Participants with normotension and hypertension (1 stage of hypertension), adult: 40 - 63 years old, physically active - no professional sportsman.
Participants with fluctuating blood pressure, with type 1 and type 2 diabetes mellitus, after a myocardial infarction, after a stroke, with an infectious disease, with grade 3 obesity, with hypertension II. - IV. degrees and individuals suffering from dizziness during exercise are excluded.
What does the study involve?
- Cardiovascular parameters - SBP, DBP, HR, PWV and augmentation index are measure by Arteriograph (TensioMed, Budapest, Hungary) at baseline, during and after training sessions.
- Body composition - Body composition is measured by InBody370S in Pavel Kolar´s Centre of Physical Medicine before intervention.
- Blood tests for heart disease - tests help determine the risk of heart diseases. it can be very helpful in assessing health. Total cholesterol, LDL, HDL, triacylglycerols, CRP, glucose are measured by NEXTCLINICS Czech a.s. before intervention
- Training intervention: Resistance training: 75% 1RM, 10 reps, 3 sets, 2 min rest between sets and exercises, 16 exercises (8 lower body exercise + 8 upper body exercise), Agonistic vs Agonistic-antagonist resistance training, freeweight + cable machines according to ACSM's Guidelines for Exercise Testing and Prescription, 11th Edition
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 40 Years 至 63 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •participants with normotension and clinical diagnosis of hypertension (1 stage of hypertension)
- •adult: 40 - 63 years old
- •physically active
- •capable of strength and aerobic training
排除标准
- •fluctuating blood pressure
- •type 1 and type 2 diabetes mellitus
- •after a myocardial infarction
- •after a stroke
- •with an infectious disease
- •with grade 3 obesity
- •hypertension II. - IV. degrees
- •suffering from dizziness during exercise
结局指标
主要结局
Arterial stiffness - Pulse wave velocity
时间窗: The training takes place twice a week, 1 training session takes 60 minutes, the total number of sessions is 5. The total length of the program is 3 weeks, duration is 5 hours.
Specifically, Aortic pulse wave velocity will be measured. The norm is up to 9 m/s, values above 9 m/s indicate impaired arterial stiffness. Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death. Decreased compliance of the central vasculature alters arterial pressure and flow dynamics and impacts cardiac performance and coronary perfusion. It is measured by Arteriograph (TensioMed, Budapest, Hungary).
Blood pressure
时间窗: The training takes place twice a week, 1 training session takes 60 minutes, the total number of sessions is 5. The total length of the program is 3 weeks, duration is 5 hours.
Measurement of changes in blood pressure level. Increase in systolic and diastolic blood pressure (mm Hg) during resistance training for agonist-antagonist and traditional agonist resistance training. Blood pressure ranges: Normal: less than 120 systolic and 80 diastolic. Elevated: 120-129 systolic and less than 80 diastolic. Stage 1 hypertension: 130-139 systolic or 80-89 diastolic. Stage 2 hypertension: at least 140 systolic or at least 90 diastolic.Investigators are looking for the safest option of resistance training for individuals with hypertension. It is measured by Arteriograph (TensioMed, Budapest, Hungary).
次要结局
- Handgrip strength(before intervention, one session, it takes 10 minutes, week 1)
- The concentration of total cholesterol(before intervention, one session, it takes 15 minutes, week 1)
- Body mass index(before intervention, one session, it takes 15 minutes, week 1)
- Abdominal wall tension(two measurements, 2x 60-90 minutes, week 1)
- Harvard step test(before intervention, one session, it takes 8 minutes, week 1)
- The Borg rating of perceived exertion(The total length of the program is 3 weeks, total duration is 5 hours. The results are recorded after each series of exercises - total 8x)
- Repetition testing(two measurements, 2x 60-90 minutes, week 1)
- Fat mass(before intervention, one session, it takes 15 minutes, week 1)
- Body fat(before intervention, one session, it takes 15 minutes, week 1)
- The concentration of low density lipoprotein (LDL)(before intervention, one session, it takes 15 minutes, week 1)
- Lean mass(before intervention, one session, it takes 15 minutes, week 1)
- Body weight(before intervention, one session, it takes 15 minutes, week 1)
- The concentration of high density lipoprotein (HDL)(before intervention, one session, it takes 15 minutes, week 1)
- The concentration of triacylglycerols(before intervention, one session, it takes 15 minutes, week 1)
- The concentration of c-reactive protein (CRP)(before intervention, one session, it takes 15 minutes, week 1)
- Blood sugar level(before intervention, one session, it takes 15 minutes, week 1)
研究者
Roman Jurik
Principal Investigator
Charles University, Czech Republic