Helium induced organ protection and the role of circulatory factors: secretion of Caveolin to the bloodstream
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
研究概览
简要总结
Smit KF, Oei GTML, Stroes ES, Nieuwland R, Schlack W, Hollmann MW, Weber NC, Preckel B: Helium induces preconditioning in the human endothelium in vivo. Anesthesiology 2013 Jan;118(1):95-104
Oei GTML, Smit KF, van de Vondenvoort D, Wieland CW, Hollmann MW, Preckel B, Weber NC; The effect of helium inhalation on the innate and early adaptive immune system ex vivo. J Transl Med 2012;10:201
Oei GTML, Huhn R, Heinen A, Hollmann MW, Schlack WS, Preckel B, Weber NC: Helium-induced cardioprotection of healthy and hypertensive rat myocardium in vivo. Eur J Pharmacol 2012; 684:125-131
Berger MM, Huhn R, Oei GTML, Heinen A, Winzer A, Preckel B, Weber NC, Schlack W, Hollmann MW: Hypoxia induces late preconditioning in the rat heart in vivo. Anesthesiology 2010; 113:1351-60
Oei GTML, Weber NC, Hollmann MW, Preckel B: Cellular effects of helium in different organs. Anesthesiology 2010; 112:1503-10.
Huhn R HA, Weber NC, Kerindongo R, Oei GTML, Hollmann MW, Schlack W, Preckel B: Helium-induced early preconditioning and postconditioning is abolished in obese Zucker rats in vivo. J Pharmacol Exp Ther 2009; 329:600-7
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •non-smoking, healthy male volunteers, aged 20-55 years
排除标准
- •-Active smoking or smoking in the previous six months
- •-Alcohol abuse or use of recreational drugs