Evaluation of β2 Genetic Polymorphisms and the Effect of Albuterol Inhalation on Potassium and Glucose Plasma Concentration
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- The extent of increase in plasma glucose concentration
研究概览
简要总结
Several studies have indicated that albuterol administered either intravenously or by inhalation can significantly reduce plasma potassium concentration in patients suffering from chronic renal failure.In conjunction with the decrease in potassium concentration a modest rise in glucose concentration is usually noted. These metabolic effects are characterized by rapid onset occurring as early as 3-5 minutes following salbutamol administration and lasting for at least 1 hour.
The role played by ß2AR polymorphisms in determining the bronchial and vascular response to ß2AR agonist drugs, have been confirmed by several studies.
The purpose of the present study is to examine possible causal relationships between genetically based alteration in the structure of ß2AR and the metabolic effects of inhaled albuterol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients regularly attending the nephrological clinic or the dialysis unit
- •persistent potassium concentration above 5 mEq/L
排除标准
- •Patients suffering from active ischemic heart disease
- •Patient with a recent history of arrhythmia
- •Patients treated regularly with ß blockers
- •Patients treated regularly with salbutamol or other ß2AR agonists
- •Patients suffering from persistent tachycardia (pulse > 100 beats/min)
- •Patients who are hemodynamically unstable
- •Patients suffering from any acute illness
结局指标
主要结局
The extent of increase in plasma glucose concentration
Plasma concentration of albuterol
The extent of decrease in plasma potassium concentration
次要结局
未报告次要终点