Assessing the Role of Nitrosomonas Eutropha on Nitrolipids in the Skin
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Alteration in microbiome diversity and species
研究概览
简要总结
We are looking to see how the addition of nitrosomonas alters the presence of nitrolipids and inflammatory cytokines on the skin.
详细描述
We are looking to see how the nitrosomonas alters nitrolipids in the skin and the inflammatory cytokines of the skin.
We will be using healthy subjects over the course of 2 weeks.
Subjects will be using a neutral cleanser for one week prior to the study, skin microbiome,facial photography, lipid and cytokine measurements will be taken at baseline. Subjects will then start using nitrosomonas spray twice daily for one week.
There is a portion of the study where the subjects will have skin microbiome, facial photography, lipid measurements, blood pressure measurements and a bloow draw before and after using the nitrosomonas spray for one week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Those aged 18 and over
- •Healthy Subjects with clear skin
排除标准
- •Adults unable to consent
- •Individuals who are not yet adults (infants, children, teenagers)
- •Pregnant women
- •Prisoners
- •Those with acne, eczema, seborrheic dermatitis, rosacea or polycystic ovarian syndrome
- •Those who have started new oral medication in the last four weeks
- •Those who have used systemic antibiotics in the last month
- •Those who have used isotretinoin in the last 6 weeks
- •Those who have used topical antibiotics or retinoid in the last two weeks.
- •Those who have autoimmune or metabolic diseases
- •Those who have changed brands of oral contraceptive within the last four weeks
- •Those who have chronic medical disorders
- •Those whose with active skin infections
- •Concomitant use of nitrates
- •Concomitant use of anti-hypertensive agents
- •Those with syncopal episodes
研究组 & 干预措施
Nitrosomonas eutropha spray
Subjects will receive nitrosmonas eutropha spray that they will apply twice a day.
干预措施: Nitrosomonas eutropha (Drug)
结局指标
主要结局
Alteration in microbiome diversity and species
时间窗: one week
We will assess the alteration in the skin microbiome over a one week period by assessing the Shannon Diversity Index
Alteration in nitrolipids in the skin
时间窗: one week
we will assess the change in nitrolipid profile of sebum collections from the skin after application of the nitrosomonas spray.
次要结局
- Alteration in skin cytokines(one week)
- Alteration in blood lipids(one week)
- Blood pressure readings(one week)