A Randomized Clinical Trial Comparing 0.75% Ropivacaine And 2% Lignocaine With 1 : 200000 Adrenaline In Minor Oral Surgery.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Onset and duration of anesthesia and analgesia, Cardiovascular effects,VAS pain score.
研究概览
简要总结
Ropivacaine hydrochloride being a long acting amide local anesthetic having long duration ( 6-7 hours) of action can be beneficial in minor oral surgical procedures like surgical extraction of impacted teeth , enucleation of small cysts ,fracture reduction ,intermaxillary fixation etc.These procedures are routinely carried out under local anesthesia but require repeated infiltration or nerve blocks with more conventional drug i.e Lignocaine hydrochloride with 1:200000 adrenaline having moderate duration of action ranging from 120-150 minutes. In patients with CVS problems in whom adrenaline is contraindicated and plain Lignocaine without vasoconstrictor fails to provide effective anesthesia for required duration , Ropivacaine hydrochloride can provide effective anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 14.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients not receiving any medications that will alter the perception of pain.
- •Patients requiring extraction of bilaterally symmetrical teeth.
排除标准
- •1.Patients with history of allergic reactions to LA of amide group and sulfides.
- •2.Patients with acute infections.
- •3.Patients taking medications like MAO inhibitors, tricyclic antidepressants , phenothiazines ,vasodepressor drugs 4.Pregnant and lactating patients.
结局指标
主要结局
Onset and duration of anesthesia and analgesia, Cardiovascular effects,VAS pain score.
时间窗: Preoperatively, | Intraoperatively at 5 minutes interval and postoperatively as required.
次要结局
- Number of additional blocks /infiltration required or any other adverse effect.