Role of Fibirnogen Like Protein 2 as Aprognostic Factor in High Grade Glioma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1
- 主要终点
- Rple of FGL2in high grade glioma as aprognostic factor
研究概览
简要总结
The study population was selected from high grade glioma pateints attending the Department of Clinical Oncology, Assiut University hospital during the period from December 2018 to September 2020, we analyzed human high grade gliomas paraffin block for FLG2 expression
详细描述
Glioblastoma is the most common malignant primary brain tumor in adults, and despite aggressive treatment, it is incurable Patient prognosis differs considerably within the different World Health Organization (WHO) grades, poorest prognosis for patients with the grade IV tumour- the glioblastoma multiform (GBM).
Fibrinogen-like protein 2 (FGL2),regulates both innate and adaptive immunity. FGL2 is a 439 amino acid secreted protein that is similar to the β- and γ-chains of fibrinogen.
Secreted FGL2 (sFGL2) is the key regulator in immunosuppression may play important role in malignant transformation of low to high by inhibiting the proliferation of T cell Study the role of fibrinogen-like protein2 on Immunosuppression and progression ，free survival and overall survival in high grade glioma
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pateints>18 years old
- •Pathologically proven high grade glioma
- •Total or subtotal resection of the tumor
- •Patients received concurrent radiation therapy with temozolomide followed by adjuvant temozolamide for 6 months
排除标准
- •Pregnancy
- •Breast feeding
- •Other comorbidity
- •Previous malignancy or radiation therapy or chemotherapy
结局指标
主要结局
Rple of FGL2in high grade glioma as aprognostic factor
时间窗: baseline
Correlation between FLG2 expression and progression free survival and overall survival
次要结局
未报告次要终点
研究者
sohaila Essam
Role of fibrinogen like protein 2 as aprognostic factor in high grade glioma
Assiut University