An Open-Label, Single-Arm, Phase II Study to Evaluate the Efficacy, Safety and CNS Exposure of G-202 (Mipsagargin) in Patients With Recurrent or Progressive Glioblastoma
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- 6-month Progression-free Survival (PFS)
研究概览
简要总结
This study will evaluate if a drug called G-202 can be safely used to treat people with glioblastoma (GBM) that has progressed or recurred. G-202 is given by intravenous infusion on three consecutive days of a 28-day cycle.
详细描述
Glioblastoma (GBM) comprises about 16% of all malignancies of the nervous system and over 50% of all gliomas. Standard of care for newly-diagnosed GBM is a combination of surgical debulking followed by concurrent radiotherapy and chemotherapy with temozolomide. Efforts to improve second-line therapy in GBM have met with only marginal success and there is a large unmet medical need for new therapies. G-202 (mipsagargin) is an example of prodrug chemotherapy. It is activated by Prostate Specific Membrane Antigen (PSMA), which is expressed by some cancer cells and in the blood vessels of most solid tumors, including GBM, but not by normal cells or blood vessels in normal tissue. It is believed that activation of the prodrug G-202 will allow the drug to kill cancer cells. This study will evaluate the activity, safety and CNS exposure of G-202 in participants with recurrent or progressive GBM receiving G-202 by intravenous infusion on three consecutive days of a 28-day cycle. Funding Source - FDA Office of Orphan Products Development (OOPD)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Written informed consent to participate in this study
- •Histological or radiological confirmation of glioblastoma
- •Recurrent or progressive GBM following at least one (1), but no more than two (2) prior regimens; one of the prior regimens must have included surgery and/or radiotherapy
- •Age > 18 years
- •Karnofsky Performance Status (KPS) ≥ 60%
- •Life expectancy > 2 months
- •Adequate hematologic, renal and hepatic function
- •Adequate coagulation profile
- •Not pregnant, nursing or planning to become pregnant; willing to use contraception
排除标准
- •Deteriorating neurological symptoms, or need for increasing doses of corticosteroids or new onset of seizures
- •Surgical resection or major surgery within 4 weeks or stereotactic biopsy within 1 week of first G-202 treatment
- •Toxicity from prior therapy (excluding alopecia) that has not resolved to ≤ Grade 1 unless otherwise specified
- •Investigational or cytotoxic therapy within 28 days or nitrosoureas within 42 days of the first treatment with G-202
- •Currently requiring any type of full-dose anti-coagulation treatment, systemic administration of antibiotics or chronic administration of anti-viral agents.
- •History or evidence of cardiac risk, including QTc interval on screening ECG >470 msec, left ventricular ejection fraction (LVEF) < 50%, clinically significant uncontrolled arrhythmias or arrhythmia requiring treatment with the exceptions of atrial fibrillation and paroxysmal supraventricular tachycardia, history of acute coronary syndromes within 6 months prior to the first dose of study therapy (including myocardial infarction and unstable angina, coronary artery bypass graft, angioplasty, or stenting)
- •Uncontrolled cardiac or coronary artery disease
- •Uncontrolled hypertension (mean systolic BP ≥ 160 mm Hg and/or mean diastolic BP ≥ 100 mm Hg on 3 determinations 5 minutes apart while on 2 anti-hypertensive agents) or hypertension requiring treatment with more than 2 anti-hypertensive agents
- •Severe or uncontrolled medical disease, including uncontrolled diabetes, congestive heart failure, chronic renal disease or chronic pulmonary disease
- •Severe GI bleeding within 12 weeks of treatment with G-202
- •Known history of HIV, hepatitis B or hepatitis C
- •Documentation of keratosis follicularis (also known as Darier or Darier-White disease)
- •Requirement for chronic use of strong inhibitors or inducers of cytochrome (CYP3A4) iso-enzymes
- •Known hypersensitivity to any study drug component including thapsigargin derivatives, polysorbate 20, or propylene glycol
- •Any other condition, including concurrent medical condition, social circumstance or drug dependency, which in the opinion of the investigator could compromise patient safety and/or compliance with study requirements
- •Another primary malignancy that has not been in remission for at least 2 years; non-melanoma skin cancer, intraepithelial carcinoma of the cervix, or prostate cancer with a current PSA ≤ 0.1 ng/mL is allowed
研究组 & 干预措施
G-202 (Mipsagargin)
G-202 (Mipsagargin) administered by intravenous infusion on 3 consecutive days of a 28-day cycle
干预措施: G-202 (Drug)
结局指标
主要结局
6-month Progression-free Survival (PFS)
时间窗: 6 months
Percentage of patients who received at least 2 cycles of G-202 and have not progressed or died within 6 months of beginning treatment with G-202. Progression is defined using Response Assessment in Neuro-Oncology Working Group (RANO) for high-grade glioma, as any of the following: by any of the following: 25% or greater increase in sum of the products of perpendicular diameters of enhancing lesions (compared with baseline if no decrease) on stable or increasing doses of corticosteroids; a significant increase in T2/FLAIR nonenhancing lesions on stable or increasing doses of corticosteroids compared with baseline scan or best response after initiation of therapy, not due to comorbid events; the appearance of any new lesions; clear progression of nonmeasurable lesions; or definite clinical deterioration not attributable to other causes apart from the tumor, or to decrease in corticosteroid dose.
次要结局
- Toxicity Assessed by CTCAE v 4.03 Criteria(Every 2 weeks for approximately one year)
- Objective Tumor Response Rate(approximately one year)
- Duration of PFS(Every 4 weeks for approximately one year)
- Overall Survival(Every 4 weeks for approximately one year)
- Biomarkers in Tumor(Within 4 weeks of receiving G-202)