A 4-period study to investigate the effects of d-amphetamine on psychomotor function in relation to dopamine release capacity in healthy male subjects - Amphetamine PET study

Centre for Human Drug Research0 个研究点目标入组 16 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

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•Age between 25 and 45 (inclusive);Body Mass Index (BMI) between 18 and 30 kg/m2 (inclusive);Naïve to drugs containing amphetamine, cocaine or MDMA (ecstacy). This includes medically prescribed amphetamines or methylphenidate. Past (but not current) recreational use of THC, or use of nicotine is allowed.;Signed informed consent prior to any study-mandated procedure.;Ability to communicate well with the investigator in the Dutch language

•Clinically significant (history of) disease as determined by medical history, physical examination, ECG or routine blood chemistry, hematology or virology tests;Clinically significant (history of) psychiatric illnesses (including substance abuse) or (history of) psychotic symptoms;Family history of relevant psychiatric disorders (first degree) and/or psychotic disorders (first and second degree);Smokes more than 10 cigarettes a day and unwilling/unable to refrain from smoking during study occasions;Positive urine drug screen for recreational drugs (i.e. cocaine, opioids, benzodiazepines, amphetamines, metamphetamines, MDMA and/or THC);Blood loss or donation outside the limits of the Dutch blood bank (Sanquin) ;Participation in a clinical study within the past three months, or participation in four or more clinical studies in the past twelve months;Exposure to procedures involving radiation in the year prior to study start.

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