The Mechanism of Non-invasive Brain Stimulation for Therapy of Chronic Auditory Verbal Hallucinations in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change of Auditory Hallucination Rating Scale score
研究概览
简要总结
The current study investigates the basic principles that underlie the efficacy of transcranial direct current stimulation for chronic auditory verbal hallucinations in schizophrenia in a multimodal design.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of schizophrenia
- •chronic auditory verbal hallucinations
- •right-handed
排除标准
- •drug abuse other than nicotine
- •severe cognitive deficits
- •severe medical conditions
- •severe neurological disorders
- •severe microangiopathy
- •history of electroconvulsive therapy
- •pregnancy or lactation
研究组 & 干预措施
verum tDCS
left-hemispheric tDCS: anode placed midway between F3 and FP1, cathode placed midway between T3 and P3
干预措施: tDCS (Device)
sham tDCS
left-hemispheric sham tDCS: anode placed midway between F3 and FP1, cathode placed midway between T3 and P3
干预措施: tDCS (Device)
结局指标
主要结局
Change of Auditory Hallucination Rating Scale score
时间窗: baseline; 3 days after intervention; 3 months after intervention
Auditory Hallucination Rating Scale score will be assessed at baseline; changes thereof at 3 days after intervention and 3 months after intervention are primary outcome measures
次要结局
- Positive And Negative Syndrome Scale(baseline; 3 days after intervention; 3 months after intervention)
研究者
Andres Neuhaus, MD
M.D.
Charite University, Berlin, Germany