The Effect of Magnesium Sulfate Added to Levobupivacaine in Continous Femoral Block on Analgesic Requirements Following Total Knee Arthroplasty
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Visual Analogue Score
研究概览
简要总结
This study is designed to investigate the effect of magnesium sulfate added to levobupivacaine in continuous femoral nerve block following total knee arthroplasty.
详细描述
Pain after knee arthroplasty is a serious concern. This study was designed to investigate the effect of magnesium sulfate added to levobupivacaine in continuous femoral nerve block on analgesic requirements following total knee arthroplasty.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for elective unilateral primary total knee arthroplasty
排除标准
- •Patient refusal to enroll in the study
- •Patient refusal of neuraxial anesthesia
- •Existence of contraindications for neuraxial anesthesia
- •Known history of allergy to any of the study drugs
研究组 & 干预措施
Group L
continuous femoral nerve block with levobupivacaine
干预措施: continuous femoral nerve block (Procedure)
Group LM
continuous femoral nerve block with levobupivacaine and magnesium sulfate
干预措施: Magnesium Sulfate (Drug)
Group LM
continuous femoral nerve block with levobupivacaine and magnesium sulfate
干预措施: continuous femoral nerve block (Procedure)
结局指标
主要结局
Visual Analogue Score
时间窗: T0:(Baseline) Postoperative 1st hour, T1: Change in 2nd, T2: Change in 4th, T3: Change in 6th, T4: Change in 12th, T5: Change in 24th, T6: Change in 36th, T7: Change in 48th, T8: Change in 72nd hours
measurement of postoperative pain using Visual Analogue Score. Minimum: 0 Maximum: 10. Higher values represent more pain, hence lower values are better
次要结局
- Analgesic consumption(T0:(Baseline) Postoperative 1st hour, T1: Change in 2nd, T2: Change in 4th, T3: Change in 6th, T4: Change in 12th, T5: Change in 24th, T6: Change in 36th, T7: Change in 48th, T8: Change in 72nd hours)
研究者
Baturay Kansu Kazbek
Principle Investigator
Ufuk University