Influence of Enteral Microbiome Composition and Microbiome Dependent Metabolites on Mortality of Patients With Cardiogenic Shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Correlation between enteral microbiome composition and mortality
研究概览
简要总结
Cardiogenic shock is associated with a high mortality. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects. The significance of the enteral micobiome on cardiovascular mortality of patients with cardiogenic shock is still not known.
This study aims to provide a deeper understanding of the role of the enteral microbiome and microbiome dependent metabolites in mortality and disease progression of patients with cardiogenic shock.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •signs of cardiogenic shock regardless of etiology
- •lactate >3mmol/L
- •and signs of organ dysfunction (urine output <30 ml/h, cold extremities, altered mental status)
- •and systolic blood pressure <90 mmHg for >30 minutes or need for vasopressor therapy
排除标准
- •pregnancy/lactation period
- •antibiotic treatment within >24h
- •chronic inflammatory bowel disease
- •short bowel syndrome
- •artificial bowel outlet
- •persistent diarrhea or vomiting in the past 3 months
- •simultaneous participation in another interfering nutrition study
- •active chemo or radiation therapy
结局指标
主要结局
Correlation between enteral microbiome composition and mortality
时间窗: Sampling will be performed within 24 hours of onset of cardiogenic shock and clinical evaluation will be performed after 1 month
Stool samples are collected and clinical evaluation will be performed at below mentioned time points
次要结局
- Correlation between SCFA serum level and mortality(Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3)
- Correlation between TMAO serum level and mortality(Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3)
- Correlation between inflammatory profile (CRP, PCT, Interleukin panel) and mortality(Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3)
研究者
Chistos Rammos
Professor Dr. med.
University Hospital, Essen