Effect of Moderate Alcohol Consumption to Cognitive Functioning After Roux-en Y Gastric Bypass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 主要终点
- Change in reaction time after alcohol consumption
研究概览
简要总结
Objectives: Alcohol metabolism is changed in gastric bypass patients, leading to faster resorption and higher alcohol peak concentrations in blood. Because of stronger alcohol effects after gastric bypass we suggest that also general cognitive function is stronger impaired.
Materials and Methods: We included 28 females (12 gastric bypass patients, 8 obese and 8 normal weight subjects) in the study. Each participant had to drink 250 ml white wine. Directly before, 10-30 min after and 45-65 min after wine consumption cognitive functions were tested by test battery for attentional performance (TAP) from Zimmermann and Fimm. During the whole examination breath-alcohol-contents (BACs) were measured every 5 minutes with breathalyser "Dräger Alcotest 7510".
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Gastric bypass group:
- •preOP BMI >35 kg/m²
- •time since bariatric surgery > 1 year
- •age 18-60 years
- •moderate drinking habits
- •obese group:
- •BMI >35 kg/m²
- •age 18-60 years
- •moderate drinking habits
- •normal weight group:
- •BMI 18.5 - 25 kg/m²
- •age 18-60 years
- •moderate drinking habits
排除标准
- •patient does not drink wine
- •usage of psychotropic drugs
- •alcoholic
- •pregnancy
结局指标
主要结局
Change in reaction time after alcohol consumption
时间窗: Change measures (baseline, 10 min, 45 min)
次要结局
未报告次要终点
研究者
Bernd Schultes
Prof. Dr. med. Bernd Schultes
eSwiss Medical & Surgical Center