A Comparative study of infusion of Ephedrine and Phenylephrine on hemodynamic stability after Spinal Anaesthesia in elderly patients undergoing lower limb Orthopaedic Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 174
- 试验地点
- 1
- 主要终点
- To compare the effect of Ephedrine and Phenylephrine on hemodynamic stability after spinal anaesthesia
研究概览
简要总结
This study is a Prospective Randomized, Parallel group study. This study consists of 3 groups where Group E who will receive Injection EPHEDRINE 30mg infusion for 30 minutes, Group P who will receive Injection PHENYLEPHRINE 250mcg infusion for 30 minutes and Control group will receive intravenous bolus injection mephentermine 6mg when required .174 patients posted for lower limb orthopedic surgeries under Spinal Anesthesia will be equally divided into 3 groups as 58 each. The study will be conducted in Shri. BM Patil Medical College Hospital and Research Centre Vijayapura, Karnataka. The primary outcome is to compare the effect of Ephedrine and Phenylephrine on hemodynamic stability after Spinal Anesthesia and secondary outcome is to compare the number of rescue doses of Ephedrine and Phenylephrine given after Spinal Anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 60.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •Age above 60 years Patients undergoing lower limb orthopaedic surgeries.
排除标准
- •Infection at the site of injection Uncontrolled hypovolemia Allergy or Hypersensitivity to Vasoconstrictors Increased intracranial pressure Coagulopathy,sepsis,fixed cardiac output states,neurological disease Uncontrolled Hypertension,Diabetes Mellitus and Heart failure Phaeochromocytoma Hypothyroidism MAO inhibitors,Tricyclic Antidepressants Phenothiazine compounds Recent MI and CABG.
结局指标
主要结局
To compare the effect of Ephedrine and Phenylephrine on hemodynamic stability after spinal anaesthesia
时间窗: 30 minutes
次要结局
- To compare the number of rescue doses of Ephedrine and Phenylephrine given after spinal anaesthesia(30 minutes)