NCT02517892已完成不适用
A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molecular Targeted Agents
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,500
- 试验地点
- 2
- 主要终点
- Type and frequency of molecular alterations in resistant tumors using whole exome sequencing
研究概览
简要总结
This is a prospective study to identify molecular mechanisms of acquired resistance to targeted therapies in patients with unresectable or metastatic cancer.
This is a protocol to study clinical characteristics and biopsy tissue of patients with oncogene-driven cancer who have had previous clinical response to targeted therapy and subsequently experience progression of disease. The tissues and other specimens will be used to carry out laboratory studies to explore the molecular basis of acquired resistance to targeted therapies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with confirmed cancer and who fulfill the following eligibility criteria will be considered eligible for this study:
- •Patient affiliated to a social security regimen
- •Patients scheduled to receive anticancer agents or currently receiving anticancer agents
- •Tumor lesion accessible to core biopsies (malignant effusions can represent an alternative)
- •Patient who is fully informed, able to comply with the protocol and who signed the informed consent.
- •Availability of initial tumor material (ideally frozen, or non-Bouin fixed paraffin embedded material) acquired before exposure to the targeted therapy Note: Patients may have received other treatments since treatment with targeted therapies including radiation or chemotherapy, before undergoing the study biopsy.
排除标准
- •Coagulation abnormality prohibiting a biopsy
结局指标
主要结局
Type and frequency of molecular alterations in resistant tumors using whole exome sequencing
时间窗: 30 days after inclusion
次要结局
未报告次要终点
研究者
研究点 (2)
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