Modelling Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Exercise Training and Public Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Effects of exercise training - brain glucose uptake
研究概览
简要总结
Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •monozygotic twins
- •body mass index (BMI) difference ≥ 2 kg/m2 and/or type 2 diabetes
- •At least one co-twin is overweight (BMI > 25 kg/m2)
排除标准
- •BMI > 60 kg/m2
- •body weight > 170 kg
- •waist circumference > 150 cm
- •mental disorder or poor compliance
- •eating disorder or excessive use of alcohol
- •active ulcus disease
- •diabetes requiring insulin treatment or fasting glucose > 10 mmol/l
- •pregnancy
- •past dose of radiation
- •claustrophobia
- •presence of ferromagnetic objects that would make MRI contraindicated
结局指标
主要结局
Effects of exercise training - brain glucose uptake
时间窗: The change from baseline to 6 months
Brain glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer.
Effects of exercise training - brain inflammation
时间窗: The change from baseline to 6 months
Brain inflammation (dimensionless; standistibution volume ratio) is measured with positron emission tomography (PET) with PK11195 tracer
次要结局
- Effects of exercise training - adipose tissue glucose uptake(The change from baseline to 6 months)
- Effects of exercise training - liver glucose uptake(The change from baseline to 6 months)
- Effects of exercise training - whole-body insulin sensitivity(The change from baseline to 6 months)
- Effects of exercise training - ectopic fat(The change from baseline to 6 months)
研究者
Jarna Hannukainen
Adjunct Professor
University of Turku