The Impact of Exercise Training to Patients With Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- CPET/6 minute walking test
研究概览
简要总结
To test the impacts of different exercise training programs to the cardiopulmonary function, muscle metabolism, and body mass composition
详细描述
Atrial fibrillation (AF) has been a global threat due to its increasing incidence and prevalence, and also its potential complications of embolic stroke and heart failure, and therefore has a great impact on life expectancy and quality of life. AF with preserved ventricular function is associated with exercise intolerance, and the effect of physical training had shown to improve life quality and heart function in the population. However, the optimal physical training modalities and intensities are not well studies.
Here we conduct a prospective, randomized, and interventional trial to investigate the effects of different exercise training programs to the burden of AF. We also exploit advanced imaging modalities, including dual x-ray absorptiometry and muscle magnetic resonance, to explore the change of body mass compositions. With this project, we will be able to explore the effects of different physical exercise modalities to the burden of AF and heart function, and also build up a best exercise training program, specific for this population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Paroxysmal or persistent atrial fibrillation
- •Daily activity below moderate intensity < 300 minutes or high intensity < 150 minutes per week.
排除标准
- •Active infection.
- •Implant cardiac pacemaker.
- •Uncontrolled hypertension.
- •Cardiopulmonary contraindication to exercise training, such as decompensated heart failure, acute pulmonary edema, unstable angina, uncontrolled arrhythmia causing hemodynamic compromise, symptomatic severe aortic stenosis, suspected dissecting aortic aneurysm, severe pulmonary hypertension, acute myocarditis, endocarditis or pericarditis, uncontrolled asthma and SpO2 < 90% at rest on room air.
- •Inability to follow verbal command or to walk on treadmill or use stationary bike.
结局指标
主要结局
CPET/6 minute walking test
时间窗: 5 months
CPET/6 minute walking test
DEXA/muscle MRI
时间窗: 5 months
DEXA/muscle MRI
AF burden
时间窗: 5 months
AF burden on 14 day ECＧ
次要结局
未报告次要终点