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临床试验/NCT01897857
NCT01897857已完成不适用

Influence of DM on Artery Blood Flow and Complications After Radial Artery Cannulation

Yonsei University1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2013年7月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
80
试验地点
1
主要终点
the compensatory changes in ulnar artery blood flow after radial artery cannulation

研究概览

简要总结

In atherosclerotic patients undergoing kidney transplantation, arterial cannulation is commonly performed for continuous monitoring of systemic blood pressure and intermittent assessment of arterial blood gases. The radial artery is the preferred artery, because of its well-documented low complication rate and easy access, but, radial artery cannulation is may associated with complications. Atherosclerosis is a systemic phenomenon, and structural changes attributable to atherosclerosis, such as luminal narrowing, intimal hyperplasia, and reduction in distensibility occur frequently throughout the arterial tree. Especially in patients with diabetes mellitus (DM), the radial artery is prone to atherosclerosis and perhaps calcification. In a recent study, it was found that the radial artery flow was decreased immediately after cannulation, but recovered to its pre-cannulation value after 5min, whereas a compensatory increase of blood flow in the ulnar artery occured immediately after cannulation, persisting until 5 min. This study enrolled the patients of ASA physical status 1-2. In the patients scheduled for elective kidney transplantation, this compensatory increase of blood flow in the ulnar artery may not be occurred, because of atherosclerosis, particularly in patients with DM. In our study, we found whether there is appropriate compensatory increase of blood flow in the ulnar artery after the radial artery cannulation in two groups, patients with DM (group DM) or without DM (group nonDM), both undergoing elective kidney transplantation.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Participant)

入排标准

年龄范围
20 Years 至 60 Years(Adult)
性别
All
接受健康志愿者
否

入选标准

  • •age > 20yrs undergoing kidney transplantation
  • •ASA physical status ≥ 3
  • •patients with DM (DM group), patients without DM (nonDM group)

排除标准

  • •coagulopathy
  • •inflammation or infection at the puncture site for cannulation
  • •a positive result on the modified Allen's test
  • •the cannulation failed twice
  • •Acute renal allograft rejection

研究组 & 干预措施

DM kidney transplantation

Experimental

patient with DM undergoing undergoing kidney transplantation

干预措施: duplex Doppler ultrasonography (Device)

without DM undergoing kidney transplantation

Active Comparator

patient without DM undergoing undergoing kidney transplantation

干预措施: duplex Doppler ultrasonography (Device)

结局指标

主要结局

the compensatory changes in ulnar artery blood flow after radial artery cannulation

时间窗: Change from Baseline in ulnar artery blood before anesthesia, before cannulation, 5 min after cannultion, 20 min after removal of the arterial catheter, 24 hous after cannulation

to evaluate the compensatory changes in ulnar artery blood flow after radial artery cannulation using duplex Doppler ultrasonography at each time point

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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