T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Cognitive change
研究概览
简要总结
T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 20 and 65 years old
- •Native Dutch speaker
- •Able to provide written informed consent
排除标准
- •History of diagnosed neurological or psychiatric disease (including traumatic head injury)
- •Current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including the use of alcohol ~8 hours prior to an appointment
- •Presence of any contraindications for MRI, MEG, or TMS (including resting motor threshold >75% of maximum stimulator output or no useful motor-evoked potential elicitable)
- •Previous rTMS treatment
研究组 & 干预措施
real rTMS
verum rTMS to the DLPFC, 1500 1Hz pulses at 120% RMT, 25 minutes total
干预措施: repetitive transcranial magnetic stimulation (rTMS) (Device)
sham rTMS
sham rTMS to the DLPFC, 1500 1Hz pulses at 120% RMT, 25 minutes total
干预措施: repetitive transcranial magnetic stimulation (rTMS) (Device)
结局指标
主要结局
Cognitive change
时间窗: baseline versus directly post-intervention (max. 8 weeks after baseline)
Change in performance on a neuropsychological test measuring cognitive functioning in the domain of executive functioning
次要结局
- Brain network change(baseline versus directly post-intervention (max. 8 weeks after baseline))
研究者
Linda Douw
Associate Professor
Amsterdam UMC, location VUmc