Comparing Postoperative Analgesic Effects of Intrathecal Morphine With Modified Thoracoabdominal Nerve Block Through Perichondral Approach in Major Abdominal Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- Comparison of postoperative opioid consumption between two groups via Patient Controlled Analgesia (PCA) device
研究概览
简要总结
Abdominal surgery causes severe postoperative pain due to retraction of the abdominal wall and direct manipulation of visceral organs. It leads to delayed postoperative recovery, increased postoperative morbidity and mortality. Intrathecal morphine, epidural analgesia and patient-controlled intravenous analgesia are used in postoperative pain management of abdominal surgeries. Intrathecal morphine is frequently used in many centers because it provides effective pain control. However; morphine has undesirable effects such as urinary retention, postoperative nausea and vomiting, and respiratory depression. Modified thoracoabdominal nerves block through perichondrial approach is a technique defined by the modification of the thoracoabdominal nerves block through perichondrial approach, in which local anesthetics are delivered only to the underside of the perichondral surface. The primary implication of this study is to compare postoperative pain scores and opioid consumption in patients undergoing major abdominal surgery with intrathecal morphine or modified thoracoabdominal nerves block through perichondrial approach.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 90 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 18 years old
- •Patients undergoing major abdominal surgery
排除标准
- •Patients with solid organ dysfunction
- •Patients who receive opioid or corticosteroid medication prior to surgery
- •Patients with bleeding diathesis
- •Patients with psychiatric disorders
- •Patients who can not be contacted after surgery
研究组 & 干预措施
Modified Thoracoabdominal Nerve BlockThrough Perichondral Approach and PCA
Modified Thoracoabdominal Nerve BlockThrough Perichondral Approach and Intravenous Patient Controlled Analgesia
干预措施: Regional Block Comparison (Procedure)
Intrathecal Morphine and Intravenous Patient Controlled Analgesia
Intrathecal Morphine 200 mcg and Intravenous Patient Controlled Analgesia (1 mg/ml morphine, 1 cc bolus, 7 min. locked
干预措施: Regional Block Comparison (Procedure)
结局指标
主要结局
Comparison of postoperative opioid consumption between two groups via Patient Controlled Analgesia (PCA) device
时间窗: 48 hours
Intravenous patient-controlled analgesia (PCA) is a system of opioid delivery that consists of an infusion pump interfaced with a timing device. Intravenous morphine consumption will be recorded via PCA device, then it will be documented in mg/kg units.
次要结局
- Postoperative pain assessment with Numeric Rating Scale (NRS)(48 hours)
- Comparison of the frequency of treatment related complications(48 hours)
- Participant satisfaction(48 hours)
研究者
Beliz Bilgili
Associate Professor
Marmara University
