ASA Prediction Using Health Data and Medication Use
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 149,422
- 试验地点
- 1
- 主要终点
- The American Society of Anesthesiologists physical status (ASA-PS) class
研究概览
简要总结
The development of a machine learning algorithm that predicts American Society of Anesthesiologist-Physical Status (ASA-PS) based on preoperative variables would not only improve clinical decision-making in patient risk stratification but also offer a more reliable tool for administrative and regulatory uses. Therefore, the development of such a machine learning tool presents a significant opportunity to advance both the science and practice of perioperative care. Incorporating medication use into the algorithm could further enhance its predictive power, as it is closely linked to systemic disease. This addition could help refine the ASA-PS classification, making it an even more valuable tool in the clinical setting.
详细描述
The American Society of Anesthesiologists Physical Status (ASA-PS) classification system is a widely used tool for assessing surgical fitness and other clinical contexts. However, its inherent subjectivity and heavy reliance on clinician judgment can lead to inconsistencies in patient risk stratification, a critical component of perioperative care. Furthermore, the ASA-PS system has been adopted for various administrative and regulatory purposes beyond its original intent, such as quality assessment by the Dutch Health and Youth Care Inspectorate (IGJ), compensation decisions by private payers in the USA, patient triage, and determining suitability for certain types of surgery.
Given the broad and critical applications of the ASA-PS system, enhancing its precision and objectivity is of paramount importance. One way to achieve this is through the development of a machine learning algorithm that predicts ASA-PS based on preoperative variables. Anesthesiologists base the ASA-PS score on the presence of systemic diseases, which can be inferred from medication use. By leveraging data such as Anatomical Therapeutic Chemical (ATC) codes, BMI, sex, age, routinely collected preoperative health data, and medication use, this algorithm could provide a more consistent and objective measure of ASA-PS.
This would not only improve clinical decision-making in patient risk stratification but also offer a more reliable tool for administrative and regulatory uses. Therefore, the development of such a machine learning tool presents a significant opportunity to advance both the science and practice of perioperative care. Incorporating medication use into the algorithm could further enhance its predictive power, as it is closely linked to systemic disease. This addition could help refine the ASA-PS classification, making it an even more valuable tool in the clinical setting.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Underwent a surgical, diagnostic or therapeutic procedure within the surgical suite of the Erasmus MC, and
- •ASA-PS score recorded in electronic medical record (EMR), and
- •A verified medication list in EMR, or a filled out preoperative anesthesiological health questionnaire registered in EMR
排除标准
- •Age <18 at moment of surgery, or
- •ASA-PS V-VI, or
- •Opt-out registered in EMR
结局指标
主要结局
The American Society of Anesthesiologists physical status (ASA-PS) class
时间窗: Day 0
The dependent response variable will be the ASA-PS class, both as a four-level variable (ASA-PS I, II, III and IV) and a two-level variable (ASA-PS I and II versus ASA-PS III and IV). The ASA-PS class was assigned to the patient and recorded in the patients file in the EMR by an anesthesiologist of resident anesthesiology as a part of the routinely performed preoperative anesthesiological screening in preparation for a procedure.
次要结局
- Performance metrics: accuracy(day 0)
- Performance metrics: precision(day 0)
- Performance metrics:recall(day 0)
- Performance metrics: F1-score(day 0)
- Performance metrics: Area Under the Receiver Operating Characteristic Curve(day 0)
- Calibration(Day 0)
- Misclassification of the ASA-PS score(Day 0)
- Explainability of the prediction model:Shapley additive explanations (SHAP)(day 0)
- Explainability of the prediction model:Local interpretable model-agnostic explanations (LIME)(day 0)
- Optimal sample size(day 0)
研究者
Jan-Wiebe Korstanje
principal investigator
Erasmus Medical Center
