A multi-centre, randomized, open label, two arm, controlled trial of SHIRO KLOMAN given along with treatment of physician’s choice versus treatment of Conventional Covid Protocol in mild to moderate symptomatic patients with SARS-CoV-2 Infection (Covid-19).

The novel coronavirus Covid-19 has caused a massive pandemic with large number of fatalities inmany countries and is shortly expected to reach the devastating levels of the1918 influenza pandemic (1). No proven effective treatments have yet beendiscovered to treat the viral pneumonia caused by Covid-19, although a fewdrugs have shown some promise. Covid-19 is caused by SARS-CoV-2 virus which isan enveloped positive sense RNA virus with an unusually large RNA genome. Other drugs active against SARS-CoV-2 are actively studied,such as protease inhibitors. But drugs with distinct and varied mechanisms ofaction are needed to propose efficient drug combinations. Here we propose aninnovative approach based on the use of the saponin drug glycyrrhizin, which webelieve can be useful to combat the virus infection and to treat the associatedrespiratory symptoms. We searched for a drug that could not only inhibit viralreplication but also interfere with the entry of the virus into cells. On theone hand, we reasoned that an amphiphilic compound like a saponin couldinterfere with the virus entry into cells, owing to the well-known membraneeffects of this class of compounds. On the other hand, we considered that atarget associated to “danger-signals†in cells, like HMGB1, could be a usefulto trigger an immune response. At present, there are no specific antiviral drugs orvaccine against COVID-19 infection for potential therapy of humans. Indesperate times like today’s, it will be worthwhile testing – SHIRO KLOMAN assupplimentary treatment for the corona virus infected patients.

SHIRO KLOMAN can be easily combined with manytypes of drugs, either to promote solubilization and bioavailability of theco-transported product as discussed above, or to complement its mechanism ofaction leading to synergistic effects in some cases.