Efficacy of Nebulized Versus Intravenous N- Acetylcysteine in Airway Clearance in Broncheictasis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 70
- 主要终点
- sputum viscosity score
研究概览
简要总结
It has been deduced that reducing the production of mucus or improving the clearance of sputum in the airway is the key to enhance the therapeutic efficacy for bronchiectasis . Mucoactive drugs are commonly used to clear the airway in mucus hypersecretion diseases. Currently, investigators have found that N-acetylcysteine (NAC), an effective mucolytic agent, not only reduces the viscosity and elasticity of sputum, but it also has anti-inflammatory and antioxidant activity.
Additionally, the Spanish guidelines on the treatment of bronchiectasis indicate that the use of N-acetylcysteine should be considered for patients with bronchiectasis and COPD. Therefore, as a classic mucolytic agent with antioxidant and anti-inflammatory properties, N-acetylcysteine can be effective in the treatment of bronchiectasis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects aged above 18 years old; with a diagnosis of bronchiectasis who are admitted to chest department due to acute exacerbation
排除标准
- •current smokers, a known allergy to N-acetylcysteine; pregnancy or lactation (for women); primary diagnosis of COPD or asthma
研究组 & 干预措施
IV N Acetyle cysteine
Intervention: N Acetyle cysteine given by IV injection
干预措施: N Acetyle cysteine given by IV injection (Drug)
Nebulized N Acetyle cysteine
Intervention: Nebulized N Acetyle cysteine
干预措施: Nebulized N Acetyle cysteine (Drug)
结局指标
主要结局
sputum viscosity score
时间窗: At the end of 1 week of treatment
Sputum viscosity score \\(0\\): Normal (liquid)\\(1\\): Mildly increased viscosity (fluid)\\(2\\): Moderately increased viscosity (viscous)\\(3\\): Severely increased viscosity (sticky)
Amount of sputum
时间窗: At the end of 1 week treatment
Expectoration difficulty score
时间窗: At the end of 1 week of treatment
Expectoration difficulty score \\(0\\): No difficulty\\(1\\): Mild difficulty\\(2\\): Moderate difficulty\\(3\\): Marked difficulty
次要结局
- Need for mechanical ventilation(At the end of 1 week of treatment)