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临床试验/NCT05646342
NCT05646342尚未招募不适用

PLR in a Good Helath Women After 24 Week of Preganancy

Mohammed VI University Hospital0 个研究点目标入组 60 人开始时间: 2023年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
60
主要终点
PLR in a good helath after 24 week of preganancy

研究概览

简要总结

fluid resuscitation is one of the bases of strategies in ICU to take in charge patients , one of the technique to evaluate preload charge , is Passive leg raising, that allows reliable prediction of fluid responsiveness even in patients with spontaneous breathing activity or arrhythmias .

In recent years, hemodynamic response to passive leg raising (PLR) has been popularized as a dynamic test of preload responsiveness [1]. This manoeuvre provides an "auto-fluid challenge" which is rapid, transient and reversible. PLR transfers blood contained in the venous reservoir of the lower extremities to the central venous compartment leading to a transient increase in preload and an increase in cardiac output by Frank-Starling mechanism in preload responsive individuals.

untille now the usseuful of PLR in Pregnancy, and also The validity of dynamic measurements of preload to predict fluid response during pregnancy are note clear in littérature .

详细描述

A total of 108 low-risk pregnant women and 54 healthy non-pregnant controls, aged >18 years, participated in the study. Pregnant women attending for the second trimester routine ultrasound screening at 17-19 weeks of gestation were informed about the study and invited to participate if they had a low-risk pregnancy and ultrasound scan did not show any fetal or placental abnormality. Those who agreed were consecutively enrolled and an appointment was made for functional hemodynamic evaluation at 22-24 weeks of gestation. Exclusion criteria were any pre-existing medical condition that may have an effect on the course of pregnancy, and a previous history of preeclampsia, gestational diabetes, intrauterine fetal growth restriction or preterm delivery. Non-pregnant controls were recruited among the nursing, administrative and laboratory staff of the hospital and university. Healthy women of reproductive age were asked to attend for hemodynamic assessment during the follicular phase between day 5 and 10 of the menstrual cycle. Women with a previous history of pregnancy complication and those with a known disease or on regular medication were excluded. Examination was performed,

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All Pregnante Women in good health after 24 week of preganancy

排除标准

  • All young women under 18 years old
  • unhealthy women

结局指标

主要结局

PLR in a good helath after 24 week of preganancy

时间窗: in all the 5 mounths

we will realise ETT before and after PLR in all women that eligible of crieria inclusion , in obstetric consultation

次要结局

未报告次要终点

研究者

发起方
Mohammed VI University Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Younes Oujidi

Doctor

Mohammed VI University Hospital

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