Interactions Between Physical Activity and Cannabis Use in Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Craving for cannabis
研究概览
简要总结
In this study the investigators will explore the relationship between physical activity and cannabis use. The investigators will compare regional brain activation detected by imaging technique(fRMI) before and after exercise in cannabis users and compare results with results from controls. The investigators hypothesize that the regional brain activation in response to visual cues (pictures related to cannabis use and food) will be different in cannabis users than in controls and that exercise will significantly alter brain responses to the cues.
详细描述
It is unknown how the response of cannabis users might compare to those of non-users in response to similar dose of physical activity. We will therefore compare brain activation during craving to cannabis, a natural reward (food) and a neutral scene (nature images). The food cues will allow us to determine if effects of exercise on brain activation and craving generalize to two different reward conditions and the nature scenes provide a neutral, no rewarding control. In addition to the analysis of predetermined regions of interest, whole-brain exploratory analyses will also be conducted to examine for additional brain regions showing associations between various conditions of interest and regional brain activation.
Specific Aims
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To explore methodological factors involved in finding the relationship between PA and cannabis use.
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to examine the effects of cannabis and food cues on brain activation and craving in cannabis users and nonusers
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to examine the effects of vigorous exercise on brain activation and craving in response to cannabis and food cues.
Our working hypothesis is that the regional brain activation in response to drug cues will be different in cannabis users than in controls and that exercise will significantly alter brain responses to these cues in both groups. Our secondary hypothesis is that exercise will tend to normalize the abnormal brain activation observed in cannabis users.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cases and Controls must:
- •Be able to understand the study and provide written informed consent.
- •Be male or female 18 -35 years of age.
- •Be in generally good health
- •If female of childbearing potential, have a negative serum pregnancy test on study day
- •Cases must:
- •Meet criteria for cannabis dependence as primary diagnosis as determined by the Substance Abuse module of SCID (Structured Clinical Interview for DSM-IV).
- •Not currently seeking treatment for cannabis dependence.
- •Have a positive urine drug test for cannabis on the study day
- •Avoid alcohol and other recreational drug use (except cannabis and/or nicotine) for 48 h before testing.
排除标准
- •Cases and Controls must not:
- •Be pregnant or lactating
- •Have implanted electrical medical device (e.g. pacemaker, vagal nerve stimulator)
- •Have non-secure metallic foreign bodies
- •Have met criteria for another axis 1 diagnosis in the past 6 months
- •Receive psychotropically active or vasoactive medications (within 6 weeks of screen day)
- •Have chronic medical illness
- •Have epilepsy
- •Have a history of head injury that required hospitalization
- •Have claustrophobia
- •Have orthopedic or other problems precluding them from performing exercise protocol
- •Have body mass index (BMI) less than 19 kg/m2
- •Weighing more than 275 pounds (MRI table limit)
- •Cases must not:
- •Have current dependence, as determined by the SCID, on any psychoactive substance other than nicotine and/or cannabinoid
- •Have any serious medical or psychiatric illnesses and/or clinically significant symptoms, which in the judgment of the PI or his/her designee would make them unsafe, or would make compliance with the study protocol difficult or put the study staff at undue risk
结局指标
主要结局
Craving for cannabis
时间窗: 1 hour
次要结局
未报告次要终点
研究者
Maciej Buchowski
Research Professor
Vanderbilt University