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临床试验/NCT01311544
NCT01311544已完成不适用

Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients

Rennes University Hospital1 个研究点 分布在 1 个国家目标入组 92 人开始时间: 2011年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
92
试验地点
1
主要终点
Images quality for each cervical and intracranial arteries

研究概览

简要总结

The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic. An ultra-fast 3D MRA originally developed for the cardiac imaging, k-t blast (Broad-use Linear Acquisition Speed-up Technique) could be used to review the supraaortic vessels. This MRA offers the following advantages: short acquisition time, wide spatial coverage (of the thoracic aorta to the distal encephalic arteries), 3D spatial resolution and high temporal resolution. These qualities are even more optimal with a high magnetic field (3T). The high temporal resolution is interesting because it provides to repeat a volume every eight seconds and thus to have a dynamic evaluation of vascular filling and to assess the vascular supply of the infarcted territory. This sequence is classified as a 4D MRA.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Men and women over 18 years
  • Eligibility for intravenous thrombolytic treatment (National Institute of Neurological Disorders and Stroke criteria)
  • Permanent ischemic stroke confirm with encephalic MRI (Magnetic Resonance Imaging)
  • Patient able of accepting protocol information
  • Patient who received information about the protocol and had not expressed its opposition to participate

排除标准

  • Pacemaker
  • Surgical ferromagnetic clips
  • Cochlear implants
  • Intraocular metallic foreign body
  • Iron implants or objects likely to concentrate the Radio Frequency field
  • Claustrophobia
  • Known intolerance to contrast media (DOTAREM)
  • Pregnant women (Beta Human Chorionic gonadotrophin performed for biological assessment of thrombolysis)
  • Patient with severe kidney with Glomerular Filtration rate < 30 ml/min
  • Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

结局指标

主要结局

Images quality for each cervical and intracranial arteries

时间窗: 6 months

次要结局

  • Quantification of carotid stenosis with NASCET classification(6 months)
  • Study of dynamic vascular consequences of carotid stenosis(6 months)

研究者

发起方
Rennes University Hospital
申办方类型
Other
责任方
Sponsor

研究点 (1)

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