CHESS-SAVE Score to Stratify Decompensation Risk in Compensated Advanced Chronic Liver Disease: an International Multicenter Study (CHESS2102)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 7
- 主要终点
- Accuracy of the CHESS-SAVE score for predicting liver decompensation
研究概览
简要总结
Compensated advanced chronic liver disease (cACLD) was associated with a high rate of variceal bleeding, ascites, and hepatic encephalopathy due to portal hypertension. In these patients, esophagogastroduodenoscopy and hepatic venous pressure gradient were recommended methods to evaluate portal hypertension. However, non-invasive predictors of outcomes to stratify care remains needed. Although the updated EASL guideline has recommended that patients with liver stiffness >20kPa or platelets <150*10^9/L had the high risk of decompensation, the criteria remains to be validated. This international multicenter study aims to develop a novel CHESS-SAVE score to further predict the risk of liver decompensation in cACLD patients.
详细描述
Compensated advanced chronic liver disease (cACLD) was associated with a high rate of variceal bleeding, ascites, and hepatic encephalopathy due to portal hypertension. In these patients, esophagogastroduodenoscopy and hepatic venous pressure gradient were recommended methods to evaluate portal hypertension. However, non-invasive predictors of outcomes to stratify care remains needed. Although the updated EASL guideline has recommended that patients with liver stiffness >20kPa or platelets <150*10^9/L had the high risk of decompensation, the criteria remains to be validated. This international multicenter study initialed and enrolled by Chinese Portal Hypertension Alliance (CHESS) aims to develop a novel CHESS-SAVE score to further predict the risk of liver decompensation in cACLD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age more than 18 years;
- •fulfilled diagnosis of cACLD based on radiological, histological features of liver cirrhosis
排除标准
- •prior liver decompensation;
- •hepatocellular carcinoma;
- •prior liver transplantation;
- •portal vein thrombosis;
- •antiplatelet or anticoagulation;
- •without screening EGD within six months of TE;
- •incomplete follow-up data.
- •HVPG cohort
- •Inclusion Criteria:
- •age more than 18 years;
- •fulfilled diagnosis of cACLD based on radiological, histological features of liver cirrhosis
- •Exclusion Criteria:
- •prior liver decompensation;
- •hepatocellular carcinoma;
- •prior liver transplantation;
- •portal vein thrombosis;
- •antiplatelet or anticoagulation;
- •without screening EGD within six months of TE;
- •without HVPG measurement;
- •non-sinusoidal portal hypertension.
结局指标
主要结局
Accuracy of the CHESS-SAVE score for predicting liver decompensation
时间窗: 3 years
To assess the accuracy of the CHESS-SAVE score to predict liver decompensation in patients with compensated advanced chronic liver disease
次要结局
未报告次要终点
研究者
Xiaolong Qi
Chief
Hepatopancreatobiliary Surgery Institute of Gansu Province