Effect of Garlic Oil Macerate on Inflammatory Mediators in Healthy Normal Weight and Obese Subjects.
试验速览
- 阶段
- 4 期
- 状态
- 暂停
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- 1. To examine the pharmacokinetics of the garlic oil macerate.
研究概览
简要总结
This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.
详细描述
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years of age and older
- •Normal subjects with BMI <25, obese subjects with BMI >30
- •Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws.
排除标准
- •Subjects on any antioxidant medication.
- •Patient on non-steroidal anti-inflammatory drug.
- •On any agent with antioxidant properties.
- •History of drug or alcohol abuse.
- •Any life threatening disease.
- •On any agent with significant antioxidant properties.
- •Taking garlic extracts in the diet regularly.
结局指标
主要结局
1. To examine the pharmacokinetics of the garlic oil macerate.
次要结局
- 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level.