JPRN-jRCT1050230049招募中Unknown
Observational study to evaluate the impact of heterogeneities of RAS/BRAF in tissue and ctDNA on the efficacy of anti EGFR antibody in advanced colorectal cancer - RAS-trace 2
Kozo Kataoka0 个研究点目标入组 240 人开始时间: 2023年6月24日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 发起方
- 入组人数
- 240
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1)Histologically proven for colorectal cancer
- •2)Clinical Stage IV or recurrent colorectal cancer for which more than 12 cycles of chemotherapy including anti-EGFR therapy is planned.
- •3)measurable lesions according to RECIST ver1.1
- •4)Presence of liver metastases
- •5) No previous history of chemotherapy and radiotherapy
- •6)Aged 20 years old and over
- •7)ECOG PS0-1
- •8)Consent for blood exam for ctDNA analy
- •9)Written informed consen
排除标准
- •1)Active other malignancies
- •2)Histologically confirmed for MMRD (MSI-H or dMMR)
- •3)Pregnancy, possible pregnancy or breastfeeding
- •4)Severe pulmonary fibrosis or emphysema
- •5)Psychiatric disease
- •6)Patients requiring systemic steroid medication
- •7) Grade 2 or greater diarrhea or sensory neuropathy
- •8)Poorly controlled hypertension
- •9)History of severe heart disease, heart failure, unstable angina within 6 months or angina attack with 6 months
- •10) active COVID-19 infection
研究者
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