The Role of Oxidative Stress and Endothelial Dysfunction in High Sodium-Induced Changes in Pulsatile Hemodynamics
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Conduit artery endothelium-dependent dilation
研究概览
简要总结
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.
详细描述
Excess dietary sodium is associated with cardiac hypertrophy independent of changes in blood pressure. Importantly, increased arterial pulsatile load predicts left ventricular hypertrophy, and thus presents a potential mechanism through which high dietary sodium augments cardiovascular disease risk.
While high sodium diets impair vascular function via an increase in oxidative stress, how high sodium influences central pulsatile hemodynamics is not known. This project aims to a) determine how impaired vascular function affects pulsatile hemodynamics and thus influences the work of the heart during periods of high sodium consumption and b) examine whether regular aerobic exercise and/or fitness protects against the deleterious effects of excess sodium.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals (age 21-45) who are either sedentary (1 or less days of exercise per week during past year) or habitually active (4 or more days of aerobic exercise per week for a minimum of 1 year)
排除标准
- •Body mass index <18 or >35
- •Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90
- •Blood donation within past 8 weeks,
- •Glucose 6 phosphate dehydrogenase (G6PD) deficiency
- •A history of cancer, diabetes, or any other chronic disease
- •A history of any heart disease
- •A history of hormone therapy
- •Use of nicotine products
- •Pregnancy
- •Nursing mothers
- •Participation in regular physical activity greater than 1 day/week- but less than 4 days/week
结局指标
主要结局
Conduit artery endothelium-dependent dilation
时间窗: On the 10th day of each arm.
Brachial artery flow mediated dilation (FMD) will be assessed by duplex ultrasound as an index of conduit artery endothelial function.
Reflected Pulse Wave Amplitude
时间窗: On the 10th day of each arm.
Aortic pressure-flow relations will be assessed non-invasively using echocardiography and peripheral artery applanation tonometry. Wave separation analysis will be used to calculate reflected pulse wave amplitude.
Arterial Stiffness
时间窗: On the 10th day of each arm.
Carotid-femoral pulse wave velocity (cf-PWV) will be assessed via applanation tonometry as an index of aortic stiffness. cf-PWV will be calculated as the difference in timing of of pulse waves at the carotid and femoral arteries divided by the distance between measurements.
次要结局
- Wave reflection timing(On the 10th day of each arm.)
- Forward Pulse Wave Amplitude(On the 10th day of each arm.)
- 24 Hour Blood Pressure(The morning of day 9 through the morning of day 10 for each arm.)