NCT00213915已完成4 期
Effects of Oral Chronic L-arginine Supplementation on Exercise and Renal Function of Heart Transplant Recipients
University Hospital, Strasbourg, France6 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2004年2月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 6
- 主要终点
- Maximal and sub maximal exercise capacity at the end of the 6 weeks L-arginine supplementation. Renal function at the end of the 6 weeks
研究概览
简要总结
- exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction
- cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation
- to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male (> 18 years old) stable heart transplant recipient for at least 6 weeks
- •Stable treatment for at least 3 months
- •Sedentary people
排除标准
- •Unstable cardiac pathology
- •Obesity (IMC > 40)
- •Participation in another study in the last month
- •Chronic renal failure (creatinine clearance < 20 ml/min)
- •Renal transplantation
- •Impossibility to practice exercise test
- •Nitrate therapy
结局指标
主要结局
Maximal and sub maximal exercise capacity at the end of the 6 weeks L-arginine supplementation. Renal function at the end of the 6 weeks
次要结局
- No secondary effects
研究者
研究点 (6)
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